Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, Justyna and Coates, Michelle and Saggar, Moninder and Al-Riyami, Lamyaa and Coltherd, Jennifer and Tay, Hwee Kee and Huggan, Judith and Janicova, Lucia and Khalaf, Abedawn and Siebeke, Ivonne and Suckling, Colin and Harnett, Margaret and Harnett, William (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44 (9). pp. 669-674. ISSN 0020-7519

[thumbnail of Rzepecka-etal-IJP2014-immunomodulatory-parasitic-helminth-product-es-62-aam] PDF (Rzepecka-etal-IJP2014-immunomodulatory-parasitic-helminth-product-es-62-aam)
Rzepecka_etal_IJP2014_immunomodulatory_parasitic_helminth_product_es_62_aam.pdf
Accepted Author Manuscript
Download (471kB)

    Abstract

    ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflamma-tory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosin- ophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

    ORCID iDs

    Rzepecka, Justyna, Coates, Michelle, Saggar, Moninder, Al-Riyami, Lamyaa, Coltherd, Jennifer, Tay, Hwee Kee, Huggan, Judith, Janicova, Lucia, Khalaf, Abedawn ORCID logoORCID: https://orcid.org/0000-0001-9162-7527, Siebeke, Ivonne, Suckling, Colin, Harnett, Margaret and Harnett, William ORCID logoORCID: https://orcid.org/0000-0001-9545-9401;
    • Item type:Article
      ID code:50093
      Dates:
      Date
      Event
      August 2014
      Published
      12 June 2014
      Published Online
      19 May 2014
      Accepted
      Notes:. Notice: This is the author's version of a work that was accepted for publication in International Journal for Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal for Parasitology, [44, 9, (August 2014)] DOI: 10.1016/j.ijpara.2014.05.001.
      Keywords:asthma, ES-62, parasitic helminth, immunomodulation, phosphorylcholine, Acanthocheilonema viteae, Immunology, Infectious Diseases, Parasitology, SDG 3 - Good Health and Well-being
      Subjects:Science > Microbiology > Immunology
      Department:Faculty of Science > Pure and Applied Chemistry
      Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
      Depositing user: Pure Administrator
      Date deposited:03 Nov 2014 11:35
      Last modified:23 Sep 2021 04:37
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/50093
    CORE (COnnecting REpositories)