Browse by Author or creator

2024

Abdelsalam, Aisha A. Abdelati and Woods, Stuart and Henriquez, Selina and Curran, Lucy and Westrop, Gareth and Roberts, Craig W. (2024) Toxoplasma gondii infection of BALB/c mice perturbs host neurochemistry. Parasite Immunology, 46 (11). e13073. ISSN 0141-9838

2021

Zin, Noraziah M. and Ismail, Aisha and Mark, David R. and Westrop, Gareth and Schniete, Jana K. and Herron, Paul (2021) Adaptation to endophytic lifestyle through genome reduction by Kitasatospora sp. SUK42. Frontiers in Bioengineering and Biotechnology, 9. 740722. ISSN 2296-4185

2019

Shaw, C. D. and Imamura, H. and Downing, T. and Blackburn, G. and Westrop, G. D. and Cotton, J. A. and Berriman, M. and Sanders, M. and Rijal, S. and Coombs, G. H. and Dujardin, J. C. and Carter, K. C. (2019) Genomic and metabolomic polymorphism among experimentally selected paromomycin-resistant Leishmania donovani strains. Antimicrobial Agents and Chemotherapy, 64. e00904-19. ISSN 0066-4804

Hargrave, Kerrie E. and Woods, Stuart and Millington, Owain and Chalmers, Susan and Westrop, Gareth D. and Roberts, Craig W. (2019) Multi-omics studies demonstrate Toxoplasma gondii-induced metabolic reprogramming of murine dendritic cells. Frontiers in Cellular and Infection Microbiology : Parasite and Host, 9. 309. ISSN 2235-2988

2017

Westrop, Gareth D. and Wang, Lijie and Blackburn, Gavin J. and Zhang, Tong and Zheng, Liang and Watson, David G. and Coombs, Graham H. (2017) Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine. PLOS One, 12 (12). e0189072. ISSN 1932-6203

2016

Scott, Fraser and Khalaf, Abedawn and Suckling, Colin and Carter, Katharine and Grant, Mary and Henderson, Catherine and Westrop, Gareth and Watson, David (2016) An evaluation of minor groove binders as anti-lung cancer therapeutics. Bioorganic and Medicinal Chemistry Letters, 26 (15). pp. 3478-3486. ISSN 0960-894X

2015

Westrop, Gareth D and Williams, Roderick A M and Wang, Lijie and Zhang, Tong and Watson, David G and Silva, Ana Marta and Coombs, Graham H (2015) Metabolomic analyses of Leishmania reveal multiple species differences and large differences in amino acid metabolism. PLOS One, 10 (9). e0136891. ISSN 1932-6203

2014

Zhang, Rong and Watson, David G. and Wang, Lijie and Westrop, Gareth D. and Coombs, Graham H. and Zhang, Tong (2014) Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites. Journal of Chromatography A, 1362. 168–179. ISSN 0021-9673

2013

Judice, W.A.S. and Manfredi, Marcella A and Souza, Gerson A. and Sansevero, Thiago M. and Almeida, Paulo C and Shida, Claudio S. and Gesteira, Tarsis F. and Juliano, Luiz and Westrop, Gareth and Sanderson, Sanya J and Coombs, Graham and Tersariol, Ivarne L.S. (2013) Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8. PLOS One, 8 (11). e80153. ISSN 1932-6203

2012

Fyfe, Paul K and Westrop, Gareth D and Silva, Ana Marta and Coombs, Graham H and Hunter, William N (2012) Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation. Proceedings of the National Academy of Sciences, 109 (29). pp. 11693-11698.

Fyfe, Paul K and Westrop, Gareth D and Ramos, Tania and Müller, Sylke and Coombs, Graham H and Hunter, William N (2012) Structure of Leishmania major cysteine synthase. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68 (7). pp. 738-743.

Morrison, Lesley S and Goundry, Amy and Faria, Marilia S and Tetley, Laurence and Eschenlauer, Sylvain C and Westrop, Gareth D and Dostalova, Anna and Volf, Petr and Coombs, Graham H and Lima, Ana Paula C A and Mottram, Jeremy C (2012) Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation. Cellular Microbiology.

2011

Moya, Ignace A and Westrop, Gareth D and Coombs, Graham H and Honek, John F (2011) Mechanistic studies on the enzymatic processing of fluorinated methionine analogs by Trichomonas vaginalis methionine γ-lyase. Biochemical Journal.

2010

Steert, Koen and Berg, Maya and Mottram, Jeremy C. and Westrop, Gareth D. and Coombs, Graham H. and Cos, Paul and Maes, Louis and Joossens, Jurgen and Van der Veken, Pieter and Haemers, Achiel and Augustyns, Koen (2010) alpha-Ketoheterocycles as inhibitors of leishmania mexicana cysteine protease CPB. ChemMedChem, 5 (10). pp. 1734-1748. ISSN 1860-7179

2009

Westrop, G.D. and Georg, I. and Coombs, G.H. (2009) The mercaptopyruvate sulfurtransferase of trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. Journal of Biological Chemistry, 284 (48). pp. 33485-33494. ISSN 1083-351X

Williams, Roderick A.M. and Westrop, Gareth D. and Coombs, G.H. (2009) Two pathways for cysteine biosynthesis in Leishmania major. Biochemical Journal, 420. pp. 451-462. ISSN 0264-6021

McMillan, P.J. and Patzewitz, E.M. and Young, S.E. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2009) Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets. Parasitology, 136 (1). pp. 27-33. ISSN 0031-1820

Gornik, S.G. and Westrop, G.D. and Coombs, G.H. and Neil, D.M. (2009) Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus. Molecular Biology Reports, 37 (4). pp. 2009-2019. ISSN 0301-4851

2008

McMillan, P.J. and Young, S.E. and Patzewitz, E.M. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2008) Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides. International Journal for Parasitology, 38. S65-S65. ISSN 0020-7519

2006

Westrop, G.D. and Goodall, Gordon and Mottram, Jeremy C. and Coombs, G.H. (2006) Cysteine biosynthesis in trichomonas vaginalis involves cysteine synthase utilizing o-phosphoserine. Journal of Biological Chemistry, 281 (35). pp. 25062-25075. ISSN 1083-351X