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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides

McMillan, P.J. and Young, S.E. and Patzewitz, E.M. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2008) Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides. International Journal for Parasitology, 38. S65-S65. ISSN 0020-7519

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Abstract

Poster presented at MAM 2008, the 3rd Molecular Approaches to Malaria Meeting. The Trichomonas vaginalis TrxR was analysed to assess the efficacy of the organotellurides against a low Mr TrxR, which act by a very different mechanism to that of the high Mr TrxR. The results that will be presented show that: (a) Selectivity of inhibition between hTrxR and PfTrxR is possible (b) Selective inhibition between high Mr and low Mr TrxR can be achieved (c) The generation of inhibitors that specifically affect parasite viability is feasible.