Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets

McMillan, P.J. and Patzewitz, E.M. and Young, S.E. and Westrop, G.D. and Coombs, G.H. and Engman, L. and Muller, S. (2009) Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets. Parasitology, 136 (1). pp. 27-33. ISSN 0031-1820

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Official URL: http://dx.doi.org/10.1017/S0031182008005131

Abstract

Thioredoxin reductase (TrxR), a NADPH-dependent disulfide oxidoreductase, is vital in numerous cellular processes including defence against reactive oxygen species, cell proliferation and signal transduction. TrxRs occur in 2 forms, a high Mr enzyme characterized by those of mammals, the malaria parasite Plasmodium falciparum and some worms, and a low Mr form is present in bacteria, fungi, plants and some protozoan parasites. Our hypothesis is that the differences between the forms can be exploited in the development of selective inhibitors. In this study, cyclodextrin- and sulfonic acid-derived organotelluriums known to inhibit mammalian TrxR were investigated for their relative efficacy against P. falciparum TrxR (PfTrxR), a high Mr enzyme, and Trichomonas vaginalis TrxR (TvTrxR), a low Mr form of TrxR. The results suggest that selective inhibition of low Mr TrxRs is a feasible goal.

Creators(s):	McMillan, P.J., Patzewitz, E.M., Young, S.E., Westrop, G.D. ORCID: https://orcid.org/0000-0002-8011-6219, Coombs, G.H., Engman, L. and Muller, S.;
Item type:	Article
ID code:	15311
Keywords:	inhibition, thioredoxin system, malaria, organotellurium compounds, Trichomonas, Plasmodium, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Infectious Diseases, Animal Science and Zoology, Parasitology
Subjects:	Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user:	Ms Ann Barker-Myles
Date deposited:	05 Feb 2010 16:14
Last modified:	01 Jan 2021 09:00
URI:	https://strathprints.strath.ac.uk/id/eprint/15311
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