Minor groove binders: some recent research in drug development

Khalaf, Abedawn I. (2009) Minor groove binders: some recent research in drug development. Current Trends in Medicinal Chemistry, 6. pp. 53-63.

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Abstract

The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is described. Also, the importance of the modifications to the lipophilic and hydrophobic moieties is discussed. It has also been shown that these DNA minor groove binding compds. can be used to treat other diseases such as sleeping sickness when the right modifications have been employed. Examples of the synthetic strategy of these polypyrroles are also highlighted in this review.

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• Item metadata

  Item type:	Article
  ID code:	34881
  Dates:	Date Event 2009 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	21 Oct 2011 12:50
  Last modified:	17 Apr 2024 00:16
  URI:	https://strathprints.strath.ac.uk/id/eprint/34881