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2024

Alanazi, S. and Doonan, J. and Lumb, F. E. and Alenzi, N. and Jabbar, S. and Al-Riyami, L. and Suckling, C. J. and Harnett, W. and Watson, D. G. (2024) Reduction in creatine metabolites in macrophages exposed to small molecule analogues of the anti-inflammatory parasitic worm product ES-62. Parasite Immunology, 46 (2). e13026. ISSN 0141-9838

2023

Harnett, Margaret M. and Lumb, Felicity E. and Crowe, Jenny and Doonan, James and Buitrago, Geraldine and Brown, Stephanie and Thom, Gillian and MacDonald, Amy and Suckling, Colin J. and Selman, Colin and Harnett, William (2023) Protection against lung pathology during obesity-accelerated ageing in mice by the parasitic worm product ES-62. Frontiers in Immunology, 14. 1285069. ISSN 1664-3224

2022

Harnett, Margaret M. and Doonan, James and Lumb, Felicity E. and Crowe, Jenny and Damink, Roel Olde and Buitrago, Geraldine and Duncombe-Moore, Josephine and Wilkinson, Debbie I. and Suckling, Colin J. and Selman, Colin and Harnett, William (2022) The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing. Frontiers in Immunology, 13. 953053. ISSN 1664-3224

2021

Corbet, Marlene and Pineda, Miguel A. and Yang, Kun and Tarafdar, Anuradha and McGrath, Sarah and Nakagawa, Rinako and Lumb, Felicity E. and Suckling, Colin J. and Harnett, William and Harnett, Margaret M. and Loukas, Alex (2021) Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts. PLOS Pathogens, 17 (11). e1010069. ISSN 1553-7366

Lumb, Felicity E. and Doonan, James and Corbet, Marlene and Pineda, Miguel A. and Harnett, Margaret M. and Harnett, William (2021) Development of acanthocheilonema viteae in meriones shawi : absence of microfilariae and production of active ES-62. Parasite Immunology, 43 (3). e12803. ISSN 0141-9838

2020

Crowe, Jenny and Lumb, Felicity E. and Doonan, James and Broussard, Margaux and Tarafdar, Anuradha and Pineda, Miguel A. and Landabaso, Carmen and Mulvey, Lorna and Hoskisson, Paul A. and Babayan, Simon A. and Selman, Colin and Harnett, William and Harnett, Margaret M. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet accelerated mouse model of ageing. PLOS Pathogens, 16 (3). e1008391. ISSN 1553-7366

2019

Lumb, Felicity E. and Crowe, Jenny and Doonan, James and Suckling, Colin J. and Selman, Colin and Harnett, Margaret M. and Harnett, William (2019) Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model. Molecular and Biochemical Parasitology, 234. 111232. ISSN 0166-6851

North, Simon J and Botchway, Kwamina and Doonan, James and Lumb, Felicity E and Dell, Anne and Harnett, William and Haslam, Stuart M (2019) Site-specific glycoproteomic characterization of ES-62 : the major secreted product of the parasitic worm Acanthocheilonema viteae. Glycobiology, 29 (8). pp. 562-571. ISSN 0959-6658

Doonan, James and Tarafdar, Anuradha and Pineda, Miguel A. and Lumb, Felicity E. and Crowe, Jenny and Khan, Aneesah M. and Hoskisson, Paul A. and Harnett, Margaret M. and Harnett, William (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nature Communications, 10. 1554. ISSN 2041-1723

2018

Doonan, James and Thomas, David and Wong, Michelle H. and Ramage, Hazel J. and Al-Riyami, Lamyaa and Lumb, Felicity E. and Bell, Kara S. and Fairlie-Clarke, Karen J. and Suckling, Colin J. and Michelsen, Kathrin S. and Jiang, Hui-Rong and Cooke, Anne and Harnett, Margaret M. and Harnett, William (2018) Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease. Molecules, 23 (10). 2669. ISSN 1420-3049

Doonan, James and Lumb, Felicity E. and Pineda, Miguel A. and Tarafdar, Anuradha and Crowe, Jenny and Khan, Aneesah M. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2018) Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis. Frontiers in Immunology, 9. 1016. ISSN 1664-3224

2017

Lumb, Felicity E. and Doonan, James and Bell, Kara S. and Pineda, Miguel A. and Corbet, Marlene and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2017) Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Scientific Reports. 1704. ISSN 2045-2322

Crowe, Jenny and Lumb, Felicity E. and Harnett, Margaret M. and Harnett, William (2017) Parasite excretory-secretory products and their effects on metabolic syndrome. Parasite Immunology. ISSN 0141-9838

2016

Janicova, L. and Rzepecka, J. and Rodgers, D.T. and Doonan, J and Bell, K. and Lumb, F.E. and Suckling, C.J. and Harnett, M.M. and Harnett, W. (2016) Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens. Parasite Immunology, 38 (6). pp. 340-351. ISSN 0141-9838

2015

Bell, Kara S. and Al-Riyami, Lamyaa and Lumb, Felicity E. and Britton, Graham J. and Poole, Alastair W. and Williams, Chris M. and Braun, Ursula and Leitges, Michael and Harnett, Margaret M. and Harnett, William (2015) The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62. Immunology Letters, 168 (1). pp. 31-40. ISSN 0165-2478

Rzepecka, Justyna and Pineda, Miguel A. and Al-Riyami, Lamyaa and Rodgers, David T. and Huggan, Judith K. and Lumb, Felicity E. and Khalaf, Abedawn I. and Meakin, Paul J. and Corbet, Marlene and Ashford, Michael L. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60. pp. 59-73. ISSN 0896-8411

Rodgers, David T. and McGrath, Mairi A. and Pineda, Miguel A. and Al-Riyami, Lamyaa and Rzepecka, Justyna and Lumb, Felicity and Harnett, William and Harnett, Margaret M. (2015) The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice. Arthritis and Rheumatology, 67 (4). pp. 1023-1035. ISSN 2326-5205

2014

Pineda, Miguel A. and Lumb, Felicity and Harnett, Margaret M. and Harnett, William (2014) ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. Molecular and Biochemical Parasitology, 194 (1-2). pp. 1-8. ISSN 0166-6851