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Article

Alanazi, Ibrahim M. and Alzahrani, Abdullah R. and Zughaibi, Torki A. and Al-Asmari, Ahmed I. and Tabrez, Shams and Henderson, Catherine and Watson, David and Grant, Mary Helen (2023) Metabolomics analysis as a tool to measure cobalt neurotoxicity : an in vitro validation. Metabolites, 13 (6). 698. ISSN 2218-1989

Laovitthayanggoon, Sarunya and Henderson, Catherine J. and McCluskey, Claire and Macdonald, Margaret and Tate, Rothwelle J. and Grant, M. Helen and Currie, Susan (2018) Cobalt administration causes reduced contractility with parallel increases in TRPC6 and TRPM7 transporter protein expression in adult rat hearts. Cardiovascular Toxicology. ISSN 1559-0259

Laovitthayanggoon, Sarunya and Grant, M. Helen and Henderson, Catherine J. and Tate, Rothwelle J. and Currie, Susan (2017) CoCl2 induced cardiotoxicity associated with CoCr alloy orthopaedic implants. Heart, 103 (S2). A4. 9. ISSN 1468-201X

Nelson, Leonard J. and Morgan, Katie and Treskes, Philipp and Samuel, Kay and Henderson, Catherine J. and LeBled, Claire and Homer, Natalie and Grant, M. Helen and Hayes, Peter C. and Plevris, John N. (2017) Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications. Basic and Clinical Pharmacology and Toxicology, 120 (1). pp. 30-37. ISSN 1742-7835

Alanazi, Ibrahim and Grant, M. Helen and Watson, David and Henderson, Catherine (2016) Comparison of the metabolism of mephedrone in cultured and in freshly isolated primary rat hepatocytes. Applied in Vitro Toxicology, 2 (4). p. 241. ISSN 2332-1539

Khreit, Osama IG and Grant, Helen M and Henderson, Catherine and Watson, David G and Sutcliffe, Oliver B (2016) Identification of novel metabolic pathways of sitagliptin (STG) by LC/MS and LC/MS2 after incubations with rat hepatcoytes. Drug Metabolism and Disposition, 7 (4). 1000220. ISSN 1521-009X

Laovitthayanggoon, Sarunya and Grant, M. Helen and Henderson, Catherine J. and Tate, Rothwelle J. and Currie, Susan (2016) Investigating cobalt toxicity in the context of joint replacement patients - cobalt uptake in primary cardiac fibroblasts and in 3T3 cells. Applied in Vitro Toxicology, 2 (4). ISSN 2332-1539

Scott, Fraser and Khalaf, Abedawn and Suckling, Colin and Carter, Katharine and Grant, Mary and Henderson, Catherine and Westrop, Gareth and Watson, David (2016) An evaluation of minor groove binders as anti-lung cancer therapeutics. Bioorganic and Medicinal Chemistry Letters, 26 (15). pp. 3478-3486. ISSN 0960-894X

Omar, Khaled and Grant, M. Helen and Henderson, Catherine and Watson, David George (2014) The complex degradation and metabolism of quercetin in rat hepatocyte incubations. Xenobiotica, 44 (12). pp. 1074-1082. ISSN 0049-8254

Agbekoh, Peter E. and Henderson, Catherine and Riches, Philip E. and Grant, M. Helen (2014) Effect of cultured rat primary hepatocytes on the mechanical properties of collagen gel matrices. European Cells and Materials, 28 (S.4). p. 77. ISSN 1473-2262

Agbekoh, Peter E. and Henderson, Catherine and Riches, Philip E. and Grant, M. Helen (2014) Collagen hydrogel matrices for primary hepatocyte culture. Toxicology Letters, 229 (Supple). S141-S142. P-2.151. ISSN 0378-4274

Omar, Khaled and Grant, M. Helen and Henderson, Catherine and Watson, David G (2014) The abundant dietary constituent ferulic acid forms a wide range of metabolites including a glutathione adduct when incubated with rat hepatocytes. Xenobiotica, 44 (5). pp. 432-437.

Nelson, L. J. and Treskes, P. and Henderson, C. J. and Homer, N. and Morgan, K. and LeBled, C. and Grant, M. H. and Plevris, J. N. (2014) Human hepatic HepaRG cells maintain high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells used in drug pharmacology applications. Journal of Hepatology, 60 (1 Supp). S176-S177. ISSN 0168-8278

Nelson, L. N. and Grant, H. G. and Henderson, C. H. and Navarro, M. N. and Plevris, J. P. and Treskes, P. T. (2013) Utility of dynamic testosterone profiling for assessing human hepatic culture systems for 3D tissue engineering/pharma applications. International Journal of Artificial Organs, 36 (8). p. 586. ISSN 0391-3988

Sinclair, J.A. and Henderson, C. and Tettey, J.N.A. and Grant, M.H. (2013) The influence of the choice of digestion enzyme used to prepare rat hepatocytes on xenobiotic uptake and efflux. Toxicology in Vitro, 27 (1). pp. 451-457. ISSN 0887-2333

Khreit, Osama Idris Gibreel and Grant, Mary and Zhang, Tong and Henderson, Catherine and Watson, David and Sutcliffe, Oliver Brook (2013) Elucidation of the phase I and phase II metabolic pathways of (+/-)-4'-nethylmethcathinone (4-MMC) and (+/-)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS2. Journal of Pharmaceutical and Biomedical Analysis, 72. pp. 177-185. ISSN 1873-264X

Hamilton, C and Henderson, C J and Ulijn, R V and Grant, M H (2012) Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes. European Cells and Materials, 23 (Suppl ). p. 30. ISSN 1473-2262

Large, Emma and Henderson, Catherine and Flint, David and Grant, Mary (2011) IGFBP-5 as a biomarker of de-differentiation in hepatocytes. Toxicology Letters, 205 (Supple). S65-S65. ISSN 0378-4274

Afolaranmi, Grace A. and Henderson, Catherine and Grant, M.Helen (2011) Effect of Chromium and Cobalt ions on phase I and phase II enzymatic activities in vitro in freshly isolated rat hepatocytes. Toxicology in Vitro, 25 (1). pp. 125-130. ISSN 0887-2333

Large, E. and Henderson, C.J. and Flint, D.J. and Grant, M.H. (2010) Oxidative stress via hydrogen peroxide and menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes. Toxicology, 278 (3). pp. 356-357. ISSN 0300-483X

Sinclair, J.A. and Henderson, C.J. and Martin, I.K. and Grant, M.H. and Tettey, J.N.A. (2009) The extent of phase I and phase II reactions is affected by the choice of enzyme used to prepare rat hepatocytes. Chemico-Biological Interactions, 179 (2-3). pp. 256-262. ISSN 0009-2797

Akbar, M. and Henderson, C.J. and Grant, M. Helen (2008) Inhibition of cell growth and glutathione depletion by calcium channel blockers. Toxicology, 253 (1-3). pp. 14-15. ISSN 0300-483X

Sinclair, J.A. and Henderson, C.J. and Martin, I.J. and Grant, M.H. and Tettey, J.N.A. (2008) MRP2 transport function in rat hepatocytes and the effect of the liver digestion enzyme. Drug Metabolism Reviews, 40 (Supple). p. 100. ISSN 0360-2532

Sinclair, J.A. and Henderson, C.J. and Martin, I.K. and Grant, M.H. and Tettey, J.N.A. (2008) Trypsin inhibitor may increase the formation of GSH conjugates of potentially toxic reactive intermediates in isolated rat hepatocytes. Journal of Pharmacy and Pharmacology, 60 (59). A24-A25. ISSN 0022-3573

Lalaouni, A. and Henderson, C.J. and Kupper, C. and Grant, M.H. (2007) The interaction of chromium (VI) with macrophages : Depletion of glutathione and inhibition of glutathione reductase. Toxicology, 236 (1-2). pp. 76-81. ISSN 0300-483X

Sinclair, J.A. and Henderson, C.J. and Martin, I.J. and Grant, M.H. and Tettey, J.N.A. (2007) Collagenase - alone or in combination for the preparation of hepatocytes? The effect on phase 1 and phase 2 biotransformations. Journal of Pharmacy and Pharmacology, 59 (S1). A16. ISSN 0022-3573

Meechan, A.J. and Henderson, C. and Bates, Catharine D. and Grant, M.H. and Tettey, J.N.A. (2006) Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats. Journal of Pharmacy and Pharmacology, 58 (10). pp. 1359-1365. ISSN 0022-3573

Kataropoulou, M. and Henderson, C.J. and Grant, M.H. (2005) Metabolic studies of hepatocytes cultured on collagen substrates modified to contain glycosaminoglycans. Tissue Engineering, 11 (7-8). pp. 1263-1273. ISSN 1076-3279

Grant, M.H. and Morgan, C. and Henderson, C.J. and Malsch, G. and Seifert, B. and Albrecht, W. and Groth, T. (2005) The viability and function of primary rat hepatocytes cultured on polymeric membranes developed for hybrid artificial liver devices. Journal of Biomedical Materials Research, 73A (3). pp. 367-375. ISSN 0021-9304

Meechan, A.J. and Henderson, C.J. and Coxon, Geoff and Tettey, J.N.A. and Grant, M.H. (2004) Evaluation of the toxicity of a substituted 2,4-thiazolidinedione moiety to isolated rat hepatocytes : relevance to glitazone toxicity. pA2 Online: E Journal of the British Pharmacological Society, 2 (4).

Ho, Gideon and Henderson, Catherine J. and Barbenel, Joseph C. and Grant, M.H. (2004) Low level laser therapy and tissue engineered skin substitutes: effect on the proliferation rate of 3T3 mouse fibroblast cells. Proceedings of SPIE: The International Society for Optical Engineering, 5610 (124).

Ho, G. and Grant, M.H. and Barbenel, J.C. and Henderson, C.J. (2003) Low level laser therapy on artificial skin substitutes : no significant effect on the proliferation rate of 3T3 mouse fibroblast cells. Lasers in Medical Science, 18. S14-S15. ISSN 0268-8921

Kataropoulou, M. and Henderson, C.J. and Grant, M.H. (2003) The influence of glycosaminoglycans and cross-linking agents on the phenotype of hepatocytes cultured on collagen gels. Human and Experimental Toxicology, 22 (2). pp. 65-71. ISSN 0960-3271

McKay, G.C. and Henderson, C.J. and Goldie, E.I. and Connel, G. and Westmoreland, C. and Grant, M.H. (2002) Cryopreservation of rat hepatocyte monolayers: cell viability and cytochrome P450 content in post-thaw cultures. Toxicology in Vitro, 16 (1). pp. 71-79. ISSN 0887-2333

Kataropoulou, M. and Henderson, C.J. and Grant, M.H. (2002) Expression of glutathione-S-transferases in hepatocytes cultured on collagen gels of different composition. Toxicology, 192. pp. 87-88. ISSN 0300-483X

Kataropoulou, M. and Henderson, C.J. and Grant, M.H. (2002) Kaempferol metabolism by rat hepatocytes cultured on different collagen substrates. Biochemical Society Transactions, 30. p. 94. ISSN 0300-5127

Denning, D.J. and Henderson, C.J. and Grant, M.H. (2002) The cytotoxicity of chromium in osteoblasts: effects on macromolecular synthesis. Journal of Materials Science: Materials in Medicine, 13 (1). pp. 47-52. ISSN 0957-4530

Ganguli, A. and Henderson, C. and Grant, M.H. and Meikle, S.T. and Lloyd, A.W. and Goldie, I. (2002) The interactions of bisphosphonates in solution and as coatings on hydroxyapatite with osteoblasts. Journal of Materials Science: Materials in Medicine, 13 (10). pp. 923-931. ISSN 0957-4530

Book Section

Kataropoulou, M. and Henderson, C.J. and Grant, M.H.; (2001) The influence of glycosaminoglycans and crosslinking agents on the phenotype of hepatocytes cultured on collagen gels. In: Transactions of the 25th Annual Meeting of the Society for Biomaterials. Society for Biomaterials. ISBN 8024572001

Conference or Workshop Item

Agbekoh, Peter and Henderson, Catherine and Riches, Philip and Grant, Mary (2015) Influence of mechanical properties of collagen on the metabolic activity of sandwich-cultured human hepatocyes. In: 13th European ISSX meeting, 2015-06-22 - 2015-06-25, TIC Building, Strathclyde University.

Omar, Khaled M. K. and Grant, Mary and Henderson, Catherine and Watson, David (2015) LC-MS analysis of the metabolism of the dietary constituent hesperidin by rat hepatocytes. In: 13th European ISSX meeting, 2015-06-22 - 2015-06-25, TIC Building, Strathclyde University.

Alwashih, Mohammad and Watson, David and Grant, Mary and Henderson, Catherine (2015) Metabolomics as a tool to investigate mephadrone as a drug of abuse in rat hepatocytes. In: 13th European ISSX meeting, 2015-06-22 - 2015-06-25, TIC Building, Strathclyde University.

Hamilton, Christopher and Henderson, Catherine and Ulijn, Rein and Grant, Mary (2012) Chemically functionalised poly(ethylene) glycol monolayers as scaffolds for primary hepatocytes: cell targeting with galactosamine. In: 3rd Tissue Engineering and Regenerative Medicine World Congress, 2012-07-02.

Grant, Mary and Henderson, Catherine and Vontivillu Mohanarengan, Subhashree and Phillips, Sion (2012) Primary culture of rat hepatocytes on 3-D glass matrics. In: British Toxicology Society Meeting, 2007-09-01.

Hamilton, Christopher and Henderson, Catherine and Ulijn, Rein and Grant, Mary (2012) Primary cultures of hepatocytes: galactosamine as a ligand of the asialoglycoprotein receptor. In: British Toxicology Society Meeting, 2007-09-01.

Large, Emma and Henderson, Catherine and Flint, David and Grant, Mary (2011) IGFBP-5 and hepatocyte differentiation. In: 40th Anniversary DMDG Meeting, 2011-08-11 - 2011-08-12. (Unpublished)

Sinclair, J.A. and Henderson, C.J. and Martin, I.K. and Grant, M.H. and Tettey, J.N.A. (2007) The digestion enzyme used in isolation procedures influences metabolic capacity of hepatocytes. In: Life Sciences 2007, 2007-07-09 - 2007-07-10, SECC.

Sinclair, J.A. and Henderson, C.J. and Grant, M.H. and Martin, I.J. and Tettey, J.N.A. (2006) The influence of digestion enzymes on the metabolic stability of rat hepatocytes. In: Drug Metabolism Discussion Group Meeting, 2006-04-27 - 2006-04-28.

Ting, L.K.S. and Wang, N. and Grant, M.H. and Henderson, C.J. (2004) Culture of rodent hepatocytes on microgrooved surfaces: application for a flat-plate bioartificial liver device. In: 1st International Bioengineering Conference 2004, Bioengineering: Challenges and Innovations, 2004-09-08 - 2004-09-10.

Kataropoulou, M. and Henderson, C.J. and Grant, M.H. (2002) The metabolism of kaempferol in primary hepatocytes cultured on collagen films and gels of different composition. In: RSC-DMG 2002: New Technologies in Drug Discovery, 2002-12-12 - 2002-12-13.