Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes.

Hamilton, C and Henderson, C J and Ulijn, R V and Grant, M H (2012) Galactosylated poly(ethylene glycol) as a scaffold for primary hepatocytes. European Cells and Materials, 23 (Suppl ). p. 30. ISSN 1473-2262

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Abstract

Maintaining stable cultures of viable and metabolically active primary hepatocytes is a long standing problem 1. Synthetic biomaterials with tuneable chemical properties may provide a suitable platform for the culture of primary cells. Hepatocytes are capable of binding terminal galactose residues via the hepatocyte asialoglycoprotein receptor (ASGPr); targeting of this receptor may facilitate binding of cells, influence morphology and ultimately improve cellular function 2