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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Inhibition of cell growth and glutathione depletion by calcium channel blockers

Akbar, M. and Henderson, C.J. and Grant, M. Helen (2008) Inhibition of cell growth and glutathione depletion by calcium channel blockers. Toxicology, 253 (1-3). pp. 14-15. ISSN 0300-483X

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Abstract

Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.