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Riley, Christopher and Ammar, Usama and Alsfouk, Aisha and Anthony, Nahoum G. and Baiget, Jessica and Berretta, Giacomo and Breen, David and Huggan, Judith and Lawson, Christopher and McIntosh, Kathryn and Plevin, Robin and Suckling, Colin J. and Young, Louise C. and Paul, Andrew and Mackay, Simon P. (2024) Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling. Molecules, 29 (15). 3515. ISSN 1420-3049

McIntosh, Kathryn and Khalaf, Yousif H. and Craig, Rachel and West, Christopher and McCulloch, Ashley and Waghmare, Ajay and Lawson, Christopher and Chan, Edmond Y.W. and MacKay, Simon and Paul, Andrew and Plevin, Robin (2023) IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling. Cellular Signalling, 107. 110684. ISSN 1873-3913

Montes, Melania and MacKenzie, Lewis and McAllister, Milly J. and Roseweir, Antonia and McCall, Pamela and Hatziieremia, Sophia and Underwood, Mark A. and Boyd, Marie and Paul, Andrew and Plevin, Robin and MacKay, Simon P. and Edwards, Joanne (2020) Determining the prognostic significance of IKKα in prostate cancer. The Prostate, 80 (14). pp. 1188-1202. ISSN 1097-0045

McCluskey, Claire and Mooney, Laura and Paul, Andrew and Currie, Susan (2019) Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium. Vascular pharmacology, 118-119. 106560. ISSN 1879-3649

Ng, Pei Y. and McIntosh, Kathryn A. and Hargrave, Gillian and Ho, Ka H. and Paul, Andrew and Plevin, Robin (2018) Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cellular Signalling, 51. pp. 59-71. ISSN 1873-3913

Martin, Tamara P. and McCluskey, Claire and Cunningham, Margaret R. and Beattie, James and Paul, Andrew and Currie, Susan (2018) CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts. Cellular Signalling. ISSN 1873-3913

Anthony, Nahoum G. and Baiget, Jessica and Berretta, Giacomo and Boyd, Marie and Breen, David and Edwards, Joanne and Gamble, Carly and Gray, Alexander I. and Harvey, Alan L. and Hatziieremia, Sophia and Ho, Ka Ho and Huggan, Judith K. and Lang, Stuart and Llona-Minguez, Sabin and Luo, Jia Lin and McIntosh, Kathryn and Paul, Andrew and Plevin, Robin J. and Robertson, Murray N. and Scott, Rebecca and Suckling, Colin J. and Sutcliffe, Oliver Brook and Young, Louise C. and MacKay, Simon P. (2017) Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers. Journal of Medicinal Chemistry, 60 (16). pp. 7043-7066. ISSN 0022-2623

Bennett, Lindsay and Quinn, Jean and McCall, Pamela and Mallon, Elizabeth A. and Horgan, Paul G. and McMillan, Donald C. and Paul, Andrew and Edwards, Joanne (2017) High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. International Journal of Cancer, 140 (7). pp. 1633-1644. ISSN 0020-7136

Bennett, Lindsay and Mallon, Elizabeth A and Horgan, Paul G. and Paul, Andrew and McMillan, Donald C. and Edwards, Joanne (2017) The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer. Oncotarget, 8 (20). pp. 33002-33013. ISSN 1949-2553

McCluskey, Claire and Paul, Andrew and Currie, Susan (2015) Pro-inflammatory signalling in vascular endothelium: a novel role for CaMKIIdelta in ageing. Heart, 101 (S4). A100-A101. ISSN 1468-201X

Martin, Tamara P. and Lawan, Ahmed and Robinson, Emma and Grieve, David J. and Plevin, Robin and Paul, Andrew and Currie, Susan (2014) Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts. Pflugers Archiv - European Journal of Physiology, 466 (2). 319–330. ISSN 0031-6768

Petch, Donna and Anderson, Rosaleen J. and Cunningham, Anne and George, Suja E. and Hibbs, David E. and Liu, Ran and Mackay, Simon P. and Paul, Andrew and Small, David A. P. and Groundwater, Paul W. (2012) Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis. Bioorganic and Medicinal Chemistry, 20 (19). pp. 5901-5914. ISSN 0968-0896

MacKenzie, Lewis and McCall, Pamela and Hatziieremia, Sophia and Catlow, Jamie and Adams, Claire and McArdle, Peter and Seywright, Morag and Tanahill, Claire and Paul, Andrew and Underwood, Mark and Mackay, Simon and Plevin, Robin and Edwards, Joanne (2012) Nuclear factor κB predicts poor outcome in patients with hormone-naive prostate cancer with high nuclear androgen receptor. Human pathology, 43 (9). pp. 1491-500. ISSN 1532-8392

Martin, Tamara P and Robinson, Emma and Harvey, Adam P and Macdonald, Margaret and Grieve, David J and Paul, Andrew and Currie, Susan (2012) Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice. Experimental Physiology, 97 (7). pp. 822-832.

Gamble, Carly and McIntosh, Kathryn and Scott, Rebecca and Ho, Ka Ho and Plevin, Robin and Paul, Andrew (2011) Inhibitory kappa B kinases as targets for pharmacological regulation. British Journal of Pharmacology, 165 (4). 802–819. ISSN 1476-5381

Syed, Nawazish-I-Husain and Tengah, Asrin and Paul, Andrew and Kennedy, Charles (2010) Characterisation of P2X receptors expressed in rat pulmonary arteries. European Journal of Pharmacology, 649 (1-3). pp. 342-348. ISSN 0014-2999

Jones, Leigh A. and Kreem, Shrook and Shweash, Muhannad and Paul, Andrew and Alexander, James and Roberts, Craig W. (2010) Differential modulation of TLR-3 and TLR-4 mediated dendritic cell maturation and function by progesterone. Journal of Immunology, 185 (8). pp. 4525-4534. ISSN 0022-1767

Pytka, Karolina and Librowski, Tadeusz and Filipek, Barbara and Paul, Andrew and Bushell, Trevor (2010) Does receptor activation initiate the NF kappa B pathway in hippocampal neurones? Pharmacological Reports, 62 (supple). p. 59. ISSN 1734-1140

MacKenzie, C. and Ritchie, E. and Paul, A. and Plevin, R.J. (2007) IKKalpha and IKKbeta function in TNFalpha-stimulated adhesion molecule expression in human aortic smooth muscle cells. Cellular Signalling, 19. pp. 75-80. ISSN 1873-3913

Currie, S. and Anthony, D.F. and Beattie, J. and Paul, A. (2007) Interaction of calcium/calmodulin-dependent protein kinase IIδC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 43 (4). pp. 492-503. ISSN 0022-2828

Hatziieremia, S. and Gray, A. and Ferro, V.A. and Paul, A. and Plevin, R.J. (2006) The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and nFkappaB signalling pathways in monocytes/macrophages. British Journal of Pharmacology, 149. pp. 188-198. ISSN 1476-5381

Cameron, P. and McGachy, H.A. and Anderson, M. and Paul, A. and Coombs, G.H. and Mottram, J.C. and Alexander, J. and Plevin, R.J. (2004) Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. Journal of Immunology, 173 (5). pp. 3297-3304. ISSN 0022-1767

Tucker, S.J. and Rae, C. and Littlejohn, A.F. and Paul, A. and MacEwan, D.J. (2004) Switching leukemia cell phenotype between life and death. Proceedings of the National Academy of Sciences, 101 (35). pp. 12940-12945. ISSN 1091-6490

Cameron, P. and Bingham, D. and Paul, A. and Pavelka, M. and Cameron, S. and Rotondo, D. and Plevin, R.J. (2002) Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa b signaling, stimulated by escherichia coli o157:H7 in vero cells. Infection and Immunity, 70 (10). pp. 5370-5380. ISSN 0019-9567

McDonald, M.C. and Mota-Filipe, H. and Paul, A. and Cuzzocrea, S. and Abdelrahman, M. and Harwood, S. and Plevin, R.J. and Chatterjee, P.K. and Yaqoob, M.M. and Thiemermann, C. (2001) Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock. FASEB Journal, 15 (1). pp. 171-186. ISSN 0892-6638

Torrie, L.J. and MacKenzie, C. and Paul, A. and Plevin, R.J. (2001) Hydrogen peroxide-mediated inhibition of lipopolysaccharide-stimulated inhibitory kappa b kinase activity in rat aortic smooth muscle cells. British Journal of Pharmacology, 134 (2). pp. 393-401. ISSN 1476-5381

Kanke, T. and MacFarlane, S.R. and Seatter, M.J. and Davenport, E.L. and Paul, A. and McKenzie, R.C. and Plevin, R.J. (2001) Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa b kinases in NCTC 2544 keratinocytes. Journal of Biological Chemistry, 276 (34). pp. 31657-31666. ISSN 1083-351X

Wakelam, M J and Pettitt, T R and Kaur, P and Briscoe, C P and Stewart, A and Paul, A and Paterson, A and Cross, M J and Gardner, S D and Currie, S (1993) Phosphatidylcholine hydrolysis : a multiple messenger generating system. Advances in Second Messenger and Phosphoprotein Research, 28. pp. 73-80. ISSN 1040-7952