Browse by Author or creator

Busquets-Hernández, Carla and Ribó, Silvia and Gratacós-Batlle, Esther and Carbajo, Daniel and Tsiotsia, Alexandra and Blanco-Canosa, Juan B. and Chamberlain, Luke H. and Triola, Gemma (2024) Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S -acylation machinery. Chemical Science, 15 (32). pp. 12845-12855. ISSN 2041-6539

Salaun, Christine and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2023) The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins. Journal of Biological Chemistry, 299 (10). 105201. ISSN 1083-351X

Butler, Liam and Locatelli, Carolina and Allagioti, Despoina and Lousa, Irina and Lemonidis, Kimon and Tomkinson, Nicholas C. O. and Salaun, Christine and Chamberlain, Luke H. (2023) S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction. Journal of Biological Chemistry, 299 (1). 102754. ISSN 1083-351X

Salaun, Christine and Takizawa, Hiroya and Galindo, Alex and Munro, Kevin R. and McLellan, Jayde and Sugimoto, Isamu and Okino, Tomotaka and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2022) Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation. Journal of Biological Chemistry, 298 (10). 102469. ISSN 1083-351X

Chamberlain, Luke H. and Shipston, Michael J. and Gould, Gwyn W. (2021) Regulatory effects of protein S-acylation on insulin secretion and insulin action. Open Biology, 11 (3). 210017. ISSN 2046-2441

Salaun, Christine and Locatelli, Carolina and Zmuda, Filip and Cabrera González, Juan and Chamberlain, Luke H. (2020) Accessory proteins of the zDHHC family of S-acylation enzymes. Journal of Cell Science, 133 (22). ISSN 0021-9533

Locatelli, Carolina and Lemonidis, Kimon and Salaun, Christine and Tomkinson, Nicholas C. O. and Chamberlain, Luke H. (2020) Identification of key features required for efficient S-acylation and plasma membrane targeting of Sprouty-2. Journal of Cell Science, 133 (21). jcs249664. ISSN 0021-9533

Zmuda, Filip and Chamberlain, Luke H. (2020) Regulatory effects of post-translational modifications on zDHHC S-acyltransferases. Journal of Biological Chemistry, 295 (43). pp. 14640-14652. ISSN 1083-351X

Salaun, Christine and Greaves, Jennifer and Tomkinson, Nicholas C. O. and Chamberlain, Luke H. (2020) The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation. Journal of Biological Chemistry, 295 (21). pp. 7501-7515. ISSN 1083-351X

Kouskou, Marianna and Thomson, David M. and Brett, Ros R. and Wheeler, Lee and Tate, Rothwelle J. and Pratt, Judith A. and Chamberlain, Luke H. (2018) Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse. Experimental Neurology, 308. pp. 35-46. ISSN 0014-4886

Ampah, Khamal K. and Greaves, Jennifer and Shun-Shion, Amber S. M. and Asnawi, Asral W. B. A. and Lidster, Jessica A. and Chamberlain, Luke H. and Collins, Mark O. and Peden, Andrew A. (2018) S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19. Journal of Cell Science. ISSN 0021-9533

Fort, Loic and Batista, José Miguel and Thomason, Peter A. and Spence, Heather J. and Whitelaw, Jamie A. and Tweedy, Luke and Greaves, Jennifer and Martin, Kirsty J. and Anderson, Kurt I. and Brown, Peter and Lilla, Sergio and Neilson, Matthew P. and Tafelmeyer, Petra and Zanivan, Sara and Ismail, Shehab and Bryant, David M. and Tomkinson, Nicholas C. O. and Chamberlain, Luke H. and Mastick, Grant S. and Insall, Robert H. and Machesky, Laura M. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20. pp. 1159-1171.

Sutherland, Linda and Ruhe, Madeleine and Gattegno-Ho, Daniela and Mann, Karanjit and Greaves, Jennifer and Koscielniak, Magdalena and Meek, Stephen and Lu, Zen and Waterfall, Martin and Taylor, Ryan and Tsakiridis, Anestis and Brown, Helen and Maciver, Sutherland K. and Joshi, Anagha and Clinton, Michael and Chamberlain, Luke H. and Smith, Austin and Burdon, Tom (2018) LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. Journal of Cell Science, 131 (18). ISSN 0021-9533

Ritchie, Louise and Tate, Rothwelle and Chamberlain, Luke H. and Robertson, Graham and Zagnoni, Michele and Sposito, Teresa and Wray, Selina and Wright, John A. and Bryant, Clare E. and Gay, Nicholas J. and Bushell, Trevor J. (2018) Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons. Neuropharmacology, 135. pp. 1-10. ISSN 0028-3908

Jamieson, Lauren E. and Greaves, Jennifer and McLellan, Jayde A. and Munro, Kevin R. and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. and Faulds, Karen and Graham, Duncan (2018) Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 197. pp. 30-36. ISSN 1386-1425

Salaun, Christine and Ritchie, Louise and Greaves, Jennifer and Bushell, Trevor J. and Chamberlain, Luke H. (2017) The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells. Molecular and Cellular Neuroscience, 85. ISSN 1044-7431

Lemonidis, Kimon and MacLeod, Ruth and Baillie, George S. and Chamberlain, Luke H. (2017) Peptide array–based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292 (42). pp. 17190-17202. ISSN 1083-351X

Lemonidis, Kimon and Salaun, Christine and Kouskou, Marianna and Diez-Ardanuy, Cinta and Chamberlain, Luke H. and Greaves, Jennifer (2017) Substrate selectivity in the zDHHC family of S-acyltransferases. Biochemical Society Transactions, 45 (3). pp. 751-758. ISSN 0300-5127

Greaves, Jennifer and Munro, Kevin R. and Davidson, Stuart C. and Riviere, Matthieu and Wojno, Justyna and Smith, Terry K. and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2017) Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proceedings of the National Academy of Sciences, 114 (8). E1365-E1374. ISSN 1091-6490

Diez Ardanuy, Cinta and Greaves, Jennifer and Munro, Kevin R. and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2017) A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Scientific Reports. 10. ISSN 2045-2322

Illison, Julia and Tian, Lijun and McClafferty, Heather and Werno, Martin and Chamberlain, Luke H. and Leiss, Veronika and Sassmann, Antonia and Offermanns, Stefan and Ruth, Peter and Shipston, Michael J. and Lukowski, Robert (2016) Obesogenic and diabetogenic effects of high-calorie nutrition require adipocyte BK channels. Diabetes, 65 (12). pp. 3621-3635. ISSN 0012-1797

Lemonidis, Kimon and Sanchez-Perez, Maria C. and Chamberlain, Luke H. (2015) Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases. Journal of Biological Chemistry. ISSN 1083-351X

Werno, Martin W. and Chamberlain, Luke H. (2015) S-acylation of the insulin-responsive aminopeptidase (IRAP) : quantitative analysis and identification of modified cysteines. Scientific Reports, 5. 12413. ISSN 2045-2322

Chamberlain, Luke H. and Shipston, Michael J. (2015) The physiology of protein S-acylation. Physiological Reviews, 95 (2). pp. 341-376. ISSN 1522-1210

Lemonidis, Kimon and Werno, Martin W. and Greaves, Jennifer and Diez Ardanuy, Cinta and Sanchez Perez, Maria C. and Salaun, Christine and Thomson, David M. and Chamberlain, Luke H. (2015) The zDHHC family of S-acyltransferases. Biochemical Society Transactions, 43 (2). pp. 217-221. ISSN 0300-5127

Kavanagh, Deirdre M. and Smyth, Annya M. and Martin, Kirsty J. and Dun, Alison and Brown, Euan R. and Gordon, Sarah and Smillie, Karen J. and Chamberlain, Luke H. and Wilson, Rhodri S. and Yang, Lei and Lu, Weiping and Cousin, Michael A. and Rickman, Colin and Duncan, Rory R. (2014) A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion. Nature Communications, 5. 5774. ISSN 2041-1723

Lemonidis, Kimon and Gorleku, Oforiwa A. and Sanchez Perez, Maria C. and Grefen, Christopher and Chamberlain, Luke H. (2014) The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Molecular Biology of the Cell, 25 (24). pp. 3870-3883. ISSN 1059-1524

Greaves, Jennifer and Chamberlain, Luke (2014) New links between S-acylation and cancer. Journal of Pathology, 233 (1). pp. 4-6. ISSN 0022-3417

Billcliff, Peter G. and Gorleku, Oforiwa A. and Chamberlain, Luke and Banting, George (2013) The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif. Open Biology, 2 (11). pp. 1253-1263. ISSN 2046-2441

Chamberlain, Luke (2013) Evolving views on protein palmitoylation (Comment on DOI 10.1002/bies.201300076). BioEssays, 35 (11). p. 928. ISSN 1521-1878

Chamberlain, Luke and Lemonidis, Kimon and Sanchez Perez, Maria Concepcion and Werno, Martin and Gorleku, Oforiwa A. and Greaves, Jennifer (2013) Palmitoylation and the trafficking of peripheral membrane proteins. Biochemical Society Transactions, 41 (1). pp. 62-66. ISSN 0300-5127

Greaves, Jennifer and Lemonidis, Kimon and Gorleku, Oforiwa and Cruchaga, Carlos and Grefen, Christopher and Chamberlain, Luke (2012) Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Journal of Biological Chemistry, 287 (44). pp. 37330-37339. ISSN 1083-351X

Gorleku, Oforiwa A and Barns, Anna-Marie and Prescott, Gerald R and Greaves, Jennifer and Chamberlain, Luke H (2011) Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. Journal of Biological Chemistry, 286. pp. 39573-39584. ISSN 1083-351X

Greaves, Jennifer and Carmichael, Juliet A and Chamberlain, Luke H (2011) The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway : regulation by a C-terminal domain. Molecular Biology of the Cell, 22 (11). pp. 1887-1895.

Greaves, Jennifer and Chamberlain, Luke H (2011) DHHC palmitoyl transferases : substrate interactions and (patho)physiology. Trends in Biochemical Sciences, 36 (5). pp. 245-253. ISSN 0968-0004

Prescott, Gerald R and Chamberlain, Luke H (2011) Regional and developmental brain expression patterns of SNAP25 splice variants. BMC Neuroscience, 12. 35.

Greaves, Jennifer and Chamberlain, Luke H (2011) Differential palmitoylation regulates intracellular patterning of SNAP25. Journal of Cell Science, 124 (8). pp. 1351-1360.

Salaun, Christine and Greaves, Jennifer and Chamberlain, Luke H (2010) The intracellular dynamic of protein palmitoylation. Journal of Cell Biology, 191 (7). pp. 1229-1238.

Greaves, Jennifer and Gorleku, Oforiwa A and Salaun, Christine and Chamberlain, Luke H (2010) Palmitoylation of the SNAP25 protein family : specificity and regulation by DHHC palmitoyl transferases. Journal of Biological Chemistry, 285 (32). pp. 24629-24638. ISSN 1083-351X

Gorleku, Oforiwa A and Chamberlain, Luke H (2010) Palmitoylation and testis-enriched expression of the cysteine-string protein beta isoform. Biochemistry, 49 (25). pp. 5308-5313. ISSN 0006-2960

Rickman, Colin and Medine, Claire N and Dun, Alison R and Moulton, David J and Mandula, Ondrej and Halemani, Nagaraj D and Rizzoli, Silvio O and Chamberlain, Luke H and Duncan, Rory R (2010) t-SNARE protein conformations patterned by the lipid microenvironment. Journal of Biological Chemistry, 285 (18). pp. 13535-13541. ISSN 1083-351X

Greaves, Jennifer and Prescott, Gerald R and Gorleku, Oforiwa A and Chamberlain, Luke H (2010) Regulation of SNAP-25 trafficking and function by palmitoylation. Biochemical Society Transactions, 38 (1). pp. 163-166.

Greaves, Jennifer and Chamberlain, Luke H (2010) S-acylation by the DHHC protein family. Biochemical Society Transactions, 38 (2). pp. 522-524.

Prescott, Gerald R and Gorleku, Oforiwa A and Greaves, Jennifer and Chamberlain, Luke H (2009) Palmitoylation of the synaptic vesicle fusion machinery. Journal of Neurochemistry, 110 (4). pp. 1135-1149.

Bournazos, Stylianos and Hart, Simon P and Chamberlain, Luke H and Glennie, Martin J and Dransfield, Ian (2009) Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity. Journal of Immunology, 182 (12). pp. 8026-8036. ISSN 0022-1767

Greaves, Jennifer and Prescott, Gerald R and Fukata, Yuko and Fukata, Masaki and Salaun, Christine and Chamberlain, Luke H (2009) The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases. Molecular Biology of the Cell, 20 (6). pp. 1845-1854.

Greenshields, Kay N and Halstead, Susan K and Zitman, Femke M P and Rinaldi, Simon and Brennan, Kathryn M and O'Leary, Colin and Chamberlain, Luke H and Easton, Alistair and Roxburgh, Jennifer and Pediani, John and Furukawa, Koichi and Furukawa, Keiko and Goodyear, Carl S and Plomp, Jaap J and Willison, Hugh J (2009) The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice. Journal of Clinical Investigation, 119 (3). pp. 595-610.

Greaves, Jennifer and Prescott, Gerald R and Gorleku, Oforiwa A and Chamberlain, Luke H (2009) The fat controller : roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review). Molecular Membrane Biology, 26 (1). pp. 67-79.

Tian, Lijun and Jeffries, Owen and McClafferty, Heather and Molyvdas, Adam and Rowe, Iain C M and Saleem, Fozia and Chen, Lie and Greaves, Jennifer and Chamberlain, Luke H and Knaus, Hans-Guenther and Ruth, Peter and Shipston, Michael J (2008) Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels. Proceedings of the National Academy of Sciences, 105 (52). pp. 21006-21011.

Greaves, Jennifer and Salaun, Christine and Fukata, Yuko and Fukata, Masaki and Chamberlain, Luke H (2008) Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Journal of Biological Chemistry, 283 (36). pp. 25014-25026. ISSN 1083-351X