The zDHHC family of S-acyltransferases

Lemonidis, Kimon and Werno, Martin W. and Greaves, Jennifer and Diez Ardanuy, Cinta and Sanchez Perez, Maria C. and Salaun, Christine and Thomson, David M. and Chamberlain, Luke H. (2015) The zDHHC family of S-acyltransferases. Biochemical Society Transactions, 43 (2). pp. 217-221. ISSN 0300-5127 (

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The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.