Regulatory effects of protein S-acylation on insulin secretion and insulin action

Chamberlain, Luke H. and Shipston, Michael J. and Gould, Gwyn W. (2021) Regulatory effects of protein S-acylation on insulin secretion and insulin action. Open Biology, 11 (3). 210017. ISSN 2046-2441 (

[thumbnail of Chamberlain-etal-OB-2021-Regulatory-effects-of-protein-S-acylation-on-insulin-secretion-and-insulin-action]
Text. Filename: Chamberlain_etal_OB_2021_Regulatory_effects_of_protein_S_acylation_on_insulin_secretion_and_insulin_action.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (1MB)| Preview


Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function. By contrast, protein S-acylation, although a widespread PTM with important functions in most physiological systems, has received far less attention. Perturbations in S-acylation are linked to various disorders, including intellectual disability, cancer and diabetes, suggesting that this less-studied modification is likely to be of considerable biological importance. As an exemplar, in this review, we focus on the newly emerging links between S-acylation and the hormone insulin. Specifically, we examine how S-acylation regulates key components of the insulin secretion and insulin response pathways. The proteins discussed highlight the diverse array of proteins that are modified by S-acylation, including channels, transporters, receptors and trafficking proteins and also illustrate the diverse effects that S-acylation has on these proteins, from membrane binding and micro-localization to regulation of protein sorting and protein interactions.