Regulation of SNAP-25 trafficking and function by palmitoylation
Greaves, Jennifer and Prescott, Gerald R and Gorleku, Oforiwa A and Chamberlain, Luke H (2010) Regulation of SNAP-25 trafficking and function by palmitoylation. Biochemical Society Transactions, 38 (1). pp. 163-166.
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The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking and exocytotic function of this essential protein.
Author(s): | Greaves, Jennifer, Prescott, Gerald R, Gorleku, Oforiwa A and Chamberlain, Luke H | Item type: | Article |
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ID code: | 32484 |
Keywords: | acyltransferases, animals, exocytosis, humans, lipoylation, protein transport, synaptosomal-associated protein 25, Therapeutics. Pharmacology, Biochemistry |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 10 Aug 2011 10:12 |
Last modified: | 24 May 2019 02:18 |
URI: | https://strathprints.strath.ac.uk/id/eprint/32484 |
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