Regulation of SNAP-25 trafficking and function by palmitoylation

Greaves, Jennifer and Prescott, Gerald R and Gorleku, Oforiwa A and Chamberlain, Luke H (2010) Regulation of SNAP-25 trafficking and function by palmitoylation. Biochemical Society Transactions, 38 (1). pp. 163-166.

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Abstract

The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this review, we discuss the mechanisms of SNAP-25 palmitoylation and how this modification regulates the intracellular trafficking and exocytotic function of this essential protein.

Author(s):Greaves, Jennifer, Prescott, Gerald R, Gorleku, Oforiwa A and Chamberlain, Luke H
Item type:Article
ID code:32484
Keywords:acyltransferases, animals, exocytosis, humans, lipoylation, protein transport, synaptosomal-associated protein 25, Therapeutics. Pharmacology, Biochemistry
Subjects:Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:10 Aug 2011 10:12
Last modified:24 May 2019 02:18
URI:https://strathprints.strath.ac.uk/id/eprint/32484
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