Picture map of Europe with pins indicating European capital cities

Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Regional and developmental brain expression patterns of SNAP25 splice variants

Prescott, Gerald R and Chamberlain, Luke H (2011) Regional and developmental brain expression patterns of SNAP25 splice variants. BMC Neuroscience, 12.

[img]
Preview
Text (Prescott-Chamberlain-BMCN-2011-Regional-and-developmental-brain-expression-patterns-of-SNAP25-splice-variants)
Prescott_Chamberlain_BMCN_2011_Regional_and_developmental_brain_expression_patterns_of_SNAP25_splice_variants.pdf - Final Published Version
License: Creative Commons Attribution 2.5 logo

Download (2MB) | Preview

Abstract

SNAP25 is an essential SNARE protein for regulated exocytosis in neuronal cells. Differential splicing of the SNAP25 gene results in the expression of two transcripts, SNAP25a and SNAP25b. These splice variants differ by only 9 amino acids, and studies of their expression to date have been limited to analysis of the corresponding mRNAs. Although these studies have been highly informative, it is possible that factors such as differential turnover of the SNAP25 proteins could complicate interpretations based entirely on mRNA expression profiles.