DHHC palmitoyl transferases : substrate interactions and (patho)physiology

Greaves, Jennifer and Chamberlain, Luke H (2011) DHHC palmitoyl transferases : substrate interactions and (patho)physiology. Trends in Biochemical Sciences, 36 (5). pp. 245-253. ISSN 0968-0004

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Abstract

S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.

ORCID iDs

Greaves, Jennifer ORCID logoORCID: https://orcid.org/0000-0001-8445-789X and Chamberlain, Luke H ORCID logoORCID: https://orcid.org/0000-0002-8701-4995;
  • Item type:Article
    ID code:32479
    Dates:
    Date
    Event
    May 2011
    Published
    Notes:Copyright © 2011 Elsevier Ltd. All rights reserved.
    Keywords:S-palmitoylation , cellular proteins, intracellular trafficking , DHHC proteins , Therapeutics. Pharmacology, Biochemistry, Molecular Biology
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:10 Aug 2011 09:06
    Last modified:18 Jun 2021 02:25
    URI:https://strathprints.strath.ac.uk/id/eprint/32479
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