DHHC palmitoyl transferases : substrate interactions and (patho)physiology

Greaves, Jennifer and Chamberlain, Luke H (2011) DHHC palmitoyl transferases : substrate interactions and (patho)physiology. Trends in Biochemical Sciences, 36 (5). pp. 245-253. ISSN 0968-0004

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Abstract

S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.

Creators(s): Greaves, Jennifer ORCID logoORCID: https://orcid.org/0000-0001-8445-789X and Chamberlain, Luke H ORCID logoORCID: https://orcid.org/0000-0002-8701-4995;
Item type:Article
ID code:32479
Notes:Copyright © 2011 Elsevier Ltd. All rights reserved.
Keywords:S-palmitoylation , cellular proteins, intracellular trafficking , DHHC proteins , Therapeutics. Pharmacology, Biochemistry, Molecular Biology
Subjects:Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:10 Aug 2011 09:06
Last modified:05 Jul 2020 18:35
URI:https://strathprints.strath.ac.uk/id/eprint/32479
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