DHHC palmitoyl transferases : substrate interactions and (patho)physiology
Greaves, Jennifer and Chamberlain, Luke H (2011) DHHC palmitoyl transferases : substrate interactions and (patho)physiology. Trends in Biochemical Sciences, 36 (5). pp. 245-253. ISSN 0968-0004
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S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.
| Creators(s): |
Greaves, Jennifer  ORCID: https://orcid.org/0000-0001-8445-789X and Chamberlain, Luke H ORCID: https://orcid.org/0000-0002-8701-4995;
| Item type: | Article |
|---|---|
| ID code: | 32479 |
| Notes: | Copyright © 2011 Elsevier Ltd. All rights reserved. |
| Keywords: | S-palmitoylation , cellular proteins, intracellular trafficking , DHHC proteins , Therapeutics. Pharmacology, Biochemistry, Molecular Biology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Pure Administrator |
| Date deposited: | 10 Aug 2011 09:06 |
| Last modified: | 12 Feb 2021 03:23 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/32479 |
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