Palmitoylation and the trafficking of peripheral membrane proteins

Chamberlain, Luke and Lemonidis, Kimon and Sanchez Perez, Maria Concepcion and Werno, Martin and Gorleku, Oforiwa A. and Greaves, Jennifer (2013) Palmitoylation and the trafficking of peripheral membrane proteins. Biochemical Society Transactions, 41 (1). pp. 62-66. ISSN 0300-5127

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Abstract

Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport systems.