Browse by Author or creator

2019

Wood, Susanna H. and Etridge, Stephen and Kennedy, Alan R. and Percy, Jonathan M. and Nelson, David J. (2019) The electrophilic fluorination of enol esters using SelectFluor : a polar two-electron process. Chemistry - A European Journal, 25 (21). pp. 5574-5585. ISSN 0947-6539

2018

McCarter, Adam W. and Sommer, Magdalana and Percy, Jonathan M. and Jamieson, Craig and Kennedy, Alan R. and Hirst, David J. (2018) Atom efficient synthesis of selectively difluorinated carbocycles through a gold(I) catalyzed cyclization. Journal of Organic Chemistry. ISSN 0022-3263

2017

Sanderson, James N. and Dominey, Andrew P. and Percy, Jonathan M. (2017) Iron-catalyzed isopropylation of electron-deficient aryl and heteroaryl chlorides. Advanced Synthesis and Catalysis. ISSN 1615-4150

2016

Percy, Jonathan M. and Emerson, Helena and Fyfe, James W. B. and Kennedy, Alan R. and Maciuk, Sergej and Orr, David and Rathouska, Lucie and Redmond, Joanna M. and Wilson, Peter G. (2016) Modular construction of fluoroarenes from a new difluorinated building block via cross-coupling/electrocyclisation/ dehydrofluorination reactions. Chemistry - A European Journal, 22 (34). pp. 12166-12175. ISSN 0947-6539

Orr, David and Percy, Jonathan M. and Harrison, Zoe A. (2016) A computational triage approach to the synthesis of novel difluorocyclopentenes and fluorinated cycloheptadienes using thermal rearrangements. Chemical Science. ISSN 2041-6520 (In Press)

Shukla, Lena and Ajram, Laura A. and Begg, Malcolm and Evans, Brian and Graves, Rebecca H. and Hodgson, Simon T. and Lynn, Sean M. and Miah, Afjal H. and Percy, Jonathan M. and Procopiou, Panayiotis A. and Richards, Stephen A. and Slack, Robert J. (2016) 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. European Journal of Medicinal Chemistry, 115. pp. 14-25. ISSN 0223-5234

2015

Percy, Jonathan M. and McCarter, Adam W. and Sewell, Alan L. and Sloan, Nikki and Kennedy, Alan R. and Hirst, David J. (2015) Developing the Saegusa-Ito cyclisation for the synthesis of difluorinated cyclohexenones. Chemistry - A European Journal, 21 (52). 19119–19127. ISSN 0947-6539

2014

Nelson, David J. and Percy, Jonathan M.; Williams, Ian H. and Williams, Nicholas H., eds. (2014) The influence of structure on reactivity in alkene metathesis. In: Advances in Physical Organic Chemistry. Advances in Physical Organic Chemistry, 48 . Academic Press, pp. 81-188. ISBN 978-0-12-800256-8

Orr, David and Percy, Jonathan and Tuttle, Tell and Kennedy, Alan and Harrison, Zoe Alicia (2014) Evaluating the thermal vinylcyclopropane rearrangement (VCPR) as a practical method for the synthesis of difluorinated cyclopentenes : experimental and computational studies of rearrangement stereospecificity. Chemistry - A European Journal, 20 (44). 14305–14316. ISSN 0947-6539

Miah, Afjal H. and Abas, Hossay and Begg, Malcolm and Marsh, Benjamin J. and O'Flynn, Daniel E. and Percy, Jonathan M. and Ford, Alison J. and Procopiou, Panayiotis A. and Richards, Steve A. (2014) Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. Bioorganic and Medicinal Chemistry, 22 (15). pp. 4298-4311. ISSN 0968-0896

Young, Allan and Vincent, Mark A and Hillier, Ian H and Percy, Jonathan M and Tuttle, Tell (2014) Forming a ruthenium isomerisation catalyst from Grubbs II : a DFT study. Dalton Transactions, 43 (22). pp. 8493-8498. ISSN 1477-9234

Nelson, D.J. and Percy, J.M. (2014) Does the rate of competing isomerisation during alkene metathesis depend on pre-catalyst initiation rate? Dalton Transactions, 43 (12). pp. 4674-4679. ISSN 1477-9234

Mondal, B. and Wilkes, R.D. and Percy, J.M. and Tuttle, T. and Black, Richard J. G. and North, C. (2014) Towards a quantitative understanding of palladium metal scavenger performance : an electronic structure calculation approach. Dalton Transactions, 43 (2). pp. 469-478. ISSN 1477-9234

Miah, A.H. and Copley, R.C.B. and O'Flynn, D. and Percy, J.M. and Procopiou, P.A. (2014) Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. Organic and Biomolecular Chemistry, 12 (11). pp. 1779-1792. ISSN 1477-0520

2013

Laurenson, J A B and Parkinson, J A and Percy, J M and Rinaudo, G and Roig, R (2013) Multigramme synthesis and asymmetric dihydroxylation of a 4-fluorobut-2E-enoate. Beilstein Journal of Organic Chemistry, 9. 2660–2668. ISSN 1860-5397

Orr, David and Tolfrey, Alexandra and Percy, Jonathan and Frieman, Joanna and Harrison, Zoe A and Campbell-Crawford, Matthew and Patel, Vipulkumar K (2013) Single-step microwave-mediated synthesis of oxazoles and thiazoles from 3-oxetanone : a synthetic and computational study. Chemistry - A European Journal, 19 (29). pp. 9655-9662. ISSN 0947-6539

Nelson, David J. and Queval, Pierre and Rouen, Mathieu and Magrez, Magaly and Toupet, Loic and Caijo, Frederic and Borre, Etienne and Laurent, Isabelle and Crevisy, Christophe and Basle, Olivier and Mauduit, Marc and Percy, Jonathan M. (2013) Synergic effects between N-heterocyclic carbene and chelating benzylidene-ether ligands toward the initiation step of Hoveyda-Grubbs type Ru complexes. ACS Catalysis, 3 (2). pp. 259-264. ISSN 2155-5435

Ashworth, Ian W. and Hillier, Ian H. and Nelson, David J and Percy, Jonathan M and Vincent, Mark A. (2013) Olefin metathesis by Grubbs−Hoveyda complexes : computational and experimental studies of the mechanism and substrate-dependent kinetics. ACS Catalysis, 3. pp. 1929-1939. ISSN 2155-5435

Ashworth, Ian W. and Nelson, David and Percy, Jonathan (2013) Solvent effects on Grubbs’ pre-catalyst initiation rates. Dalton Transactions, 42 (12). pp. 4110-4113. ISSN 1477-9234

2012

Ashworth, Ian W. and Hillier, Ian H. and Nelson, David J and Percy, Jonathan M and Vincent, Mark A. (2012) Searching for the hidden hydrides : the competition between alkene isomerization and metathesis with Grubbs catalysts. European Journal of Organic Chemistry, 2012 (29). 5673–5677. ISSN 1434-193X

Wilson, Peter G and Percy, Jonathan M and Redmond, Joanna and McCarter, Adam W. (2012) Suzuki−Miyaura coupling reactions of iodo(difluoroenol) derivatives, fluorinated building blocks accessible at near-ambient temperatures. Journal of Organic Chemistry, 77 (15). pp. 6384-6393. ISSN 0022-3263

2011

Nelson, David J and Ashworth, Ian W. and Hillier, Ian H. and Kyne, Sara H and Pandian, Shanthi and Parkinson, John A and Percy, Jonathan M and Rinaudo, Giuseppe and Vincent, Mark A. (2011) Why is RCM favoured over dimerisation? Predicting and estimating thermodynamic effective molarities by solution experiments and electronic structure calculations. Chemistry - A European Journal, 17 (46). pp. 13087-13094. ISSN 1521-3765

Wilson, Peter and Percy, Jonathan M. and Redmond, Joanna M. (2011) Negishi coupling of metallated difluoroenol derivatives based on trifluoroethanol. Abstracts of papers - American Chemical Society, 242. FLUO-65.

Ashworth, Ian W. and Hillier, Ian H. and Nelson, David J. and Percy, Jonathan M. and Vincent, Mark A. (2011) What is the initiation step of the Grubbs-Hoveyda olefin metathesis catalyst? Chemical Communications, 47 (19). pp. 5428-5430. ISSN 1359-7345

Hillier, I.H. and Pandian, S. and Percy, Jonathan and Vincent, M.A. (2011) Mapping the potential energy surfaces for ring-closing metathesis reactions of prototypical dienes by electronic structure calculations. Dalton Transactions, 40 (5). pp. 1061-1072. ISSN 1477-9234

Kyne, Sara H and Percy, Jonathan M and Pullin, Robert D C and Redmond, Joanna M and Wilson, Peter G (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 1477-0520

Nelson, David J. and Carboni, Davide and Ashworth, Ian W. and Percy, Jonathan M. (2011) Toward a simulation approach for alkene ring-closing metathesis : scope and limitations of a model for RCM. Journal of Organic Chemistry, 76 (20). pp. 8386-8393. ISSN 0022-3263

2010

Ashworth, Ian W. and Carboni, Davide and Hillier, Ian H. and Nelson, David J. and Percy, Jonathan M. and Rinaudo, Giuseppe and Vincent, Mark A. (2010) On the relationship between structure and reaction rate in olefin ring-closing metathesis. Chemical Communications, 46 (38). pp. 7145-7147. ISSN 1359-7345

2009

Pandian, Shanthi and Hillier, Ian H. and Vincent, Mark A. and Burton, Neil A. and Ashworth, Ian W. and Nelson, David J. and Percy, Jonathan M. and Rinaudo, Giuseppe (2009) Prediction of ring formation efficiency via diene ring closing metathesis (RCM) reactions using the M06 density functional. Chemical Physics Letters, 476 (1-3). pp. 37-40. ISSN 0009-2614

Laurenson, J.A.B. and Meiries, S. and Percy, J.M. and Roig, R., University of Leicester (Funder), Engineering and Physical Sciences Research Council (EPSRC) (Funder), WestCHEM (Funder) (2009) Allylic fluorination via an unusual alkene z/e isomerisation. Tetrahedron Letters, 50 (26). pp. 3571-3573. ISSN 0040-4039

Percy, J.M. and Roig, R. and Singh, K. (2009) Fluorinated analogues of amicetose and rhodinose - novel racemic and asymmetric routes. European Journal of Organic Chemistry (7). pp. 1058-1071. ISSN 1434-193X

Caravano, Audrey and Field, Robert A. and Percy, Jonathan M. and Rinaudo, Giuseppe and Roig, Ricard and Singh, Kuldip. (2009) Developing an asymmetric, stereo-divergent route to selected 6-deoxy-6-fluoro-hexoses. Organic and Biomolecular Chemistry, 7 (5). pp. 996-1008. ISSN 1477-0520

Errey, J.C. and Mann, M.C. and Fairhurst, S.A. and Hill, L. and McNeil, M.R. and Naismith, J.H. and Percy, J.M. and Whitfield, C. (2009) Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: Fluorinated substrates, kinetics and equilibria. Organic and Biomolecular Chemistry, 7 (5). pp. 1009-1016. ISSN 1477-0520

Anderl, Timo and Audouard, Christophe and Miah, Afjal and Percy, Jonathan M. and Rinaudo, Giuseppe and Singh, Kuldip. (2009) Syntheses of difluorinated carbasugar phosphates from trifluoroethanol. Organic and Biomolecular Chemistry, 7 (24). pp. 5200-5206. ISSN 1477-0520

Ashworth, Ian W. and Miles, Jonathan A. L. and Nelson, David J. and Percy, Jonathan M. and Singh, Kuldip. (2009) Tri-substituted cyclooctene synthesis at the limits of relay ring-closing metathesis: a racemic difluorinated analog of fucose. Tetrahedron, 65 (46). pp. 9637-9646. ISSN 0040-4020

Audouard, Christophe and Bettaney, Kim and Doan, Châu T. and Rinaudo, Giuseppe and Jervis, Peter J. and Percy, Jonathan M. (2009) An appraisal of oxoketene cycloaddition methodology for the synthesis of 2,6-dideoxysugars and fluorinated 2,6-dideoxysugars. Organic and Biomolecular Chemistry, 7 (8). pp. 1573-1582. ISSN 1477-0520

2008

Kerouredan, E. and Percy, J.M. and Rinaudo, G. and Singh, K. (2008) A concise route to difluorinated analogues of cyclitols and sugars. Synthesis (24). pp. 3903-3918. ISSN 0039-7881

Mitchell, L. and Parkinson, J.A. and Percy, Jonathan and Singh, K. (2008) Selected substituent effects on the rate and efficiency of formation of an eight-membered ring by RCM. Journal of Organic Chemistry, 73 (6). pp. 2389-2395. ISSN 0022-3263

2007

Miles, Jonathan A. L. and Mitchell, Lisa and Percy, Jonathan M. and Singh, Kuldip and Uneyama, E. (2007) Total syntheses of conformationally-locked difluorinated pentopyranose analogues and a pentopyranosyl phosphate mimetic. Journal of Organic Chemistry, 72 (5). pp. 1575-1587. ISSN 0022-3263

2006

Griffith, Gerry A. and Hillier, Ian H. and Percy, Jonathan M. and Roig, Ricard and Vincent, Mark A. (2006) Quantifying the reactivity of a remarkably long-lived difluorinated enol in acidic methanol via solution kinetics and electronic structure calculations. Journal of Organic Chemistry, 71 (21). pp. 8250-8255. ISSN 0022-3263

Percy, J.M. and Griffith, G.A. and Hillier, I.H. and Vincent, M.A. and Moralee, A.C. and Roig, R. (2006) The interplay of structure and reactivity in a most unusual furan diels-alder reaction. Journal of American Chemical Society, 128 (40). pp. 13130-13141. ISSN 0002-7863

2005

Fawcett, J. and Percy, Jonathan and Pintat, S. and Smith, C.A. and Uneyama, E. (2005) (1R*,3S*,8S*)-2,2-Difluoro-3,8-dihydroxy-5,5-dimethylcyclooct-4(Z)-en-1-yl N,N-diethylcarbamate. Acta Crystallographica Section E: Structure Reports, 61 (10). O3322-O3323. ISSN 1600-5368

Fawcett, J. and Percy, Jonathan and Pintat, S. and Smith, C.A. and Uneyama, E. (2005) (1S*,2S*,4S*)-3,3-Difluoro-2,4-dihydroxy-5,5-dimethylcyclooct-5(Z)-en-1-yl N,N-diethylcarbamate. Acta Crystallographica Section E: Structure Reports, 61 (10). O3319-O3321. ISSN 1600-5368

Audouard, Christophe and Garayt, Maxime R and Kerouredan, Erwan and Percy, Jonathan and Yang, Hongli (2005) A direct and rapid route to α,α-difluoroacylsilanes from trifluoroethanol. Journal of Fluorine Chemistry, 126 (4). 609–621.

Cox, Liam R and DeBoos, Gareth A and Fullbrook, Jeremy J and Percy, Jonathan and Spencer, Neil (2005) Applying asymmetric dihydroxylation to the synthesis of difluorinated carbohydrate analogues: a 1,1-difluoro-1-deoxy-D-xylulose. Tetrahedron: Asymmetry, 16 (2). pp. 347-359. ISSN 0957-4166

Crowley, Patrick J and Fawcett, John and Griffith, Gerry A and Moralee, Andrew C and Percy, Jonathan and Salafia, Vittoria (2005) Highly-functionalised difluorinated cyclohexane polyols via the Diels–Alder reaction : regiochemical control via the phenylsulfonyl group. Organic and biomolecular chemistry (18). pp. 3297-3310. ISSN 1477-0520

Percy, J.M. and Griffith, G.A. and Pintat, S. and Smith, C.A. and Spencer, N. and Uneyama, E. (2005) Towards novel difluorinated sugar mimetrics; syntheses and conformational analyses of highly-functionalised difluorinated cyclooctenones. Organic and Biomolecular Chemistry, 3. pp. 2701-2712.

2004

Percy, Jonathan (2004) Geminally-difluorinated pharmaceutical agents : synthesis and applications. Chimca Oggi, 22 (4). pp. 18-25. ISSN 0392-839X

Arany, Andrea and Crowley, Patrick J and Fawcett, John and Hursthouse, Michael B. and Kariuki, Benson M and Light, Mark E. and Moralee, Andrew C and Percy, Jonathan and Salafia, Vittoria (2004) Highly-functionalised difluorinated (hydroxymethyl)conduritol analogues via the Diels-Alder reactions of a difluorinated dienophile. Organic and Biomolecular Chemistry, 2 (4). pp. 455-465. ISSN 1477-0520

Percy, J.M. and Audouard, C. and Fawcett, J. and Griffith, G.A. and Pintat, S. and Smith, C.A. (2004) Synthesis of 4,4-difluoroglycosides using ring-closing metathesis. Organic and Biomolecular Chemistry, 2. pp. 528-541.

Fawcett, John and Griffiths, Gerry A and Percy, Jonathan and Pintat, Stephane and Smith, Clive A and Spencer, Neil S and Uneyama, Emi (2004) Towards conformationally-locked difluorosugar analogues : an unexpected sense of dihydroxylation. Chemical Communications, 2004 (3). pp. 302-303. ISSN 1359-7345

Fawcett, John and Griffith, Gerry A and Percy, Jonathan and Uneyama, Emi (2004) Unexpectedly selective formation and reactions of epoxycyclooctenones under microwave-mediated conditions. Organic Letters, 6 (8). pp. 1277-1280. ISSN 1523-7060

Audouard, Christophe and Fawcett, John and Griffith, Gerry A and Kerouredan, Erwan and Miah, Afjal Hussain and Percy, Jonathan and Yang, Hongli (2004) A potentially divergent and rapid route to analogues of deoxycyclitols, pentopyranoses, 6-deoxyhexoses, and hexoses. Organic Letters, 6 (23). pp. 4269-4272. ISSN 1523-7060

Audouard, Christophe and Barsukov, Igor and Fawcett, John and Griffith, Gerry A and Percy, Jonathan and Pintat, Stephane and Smith, Clive A (2004) A stereodivergent asymmetric approach to difluorinated aldonic acids. Chemical Communications (13). pp. 1526-1527. ISSN 1359-7345

Fawcett, J. and Moralee, A.C. and Percy, Jonathan and Salafia, Vittoria and Vincent, M.A. and Hillier, I.H. (2004) A surprising steric effect on a tandem cycloaddition/ring-opening reaction : rapid syntheses of difluorinated analogues of (hydroxymethyl)conduritols. Chemical Communications, 2004 (9). pp. 1062-1063. ISSN 1359-7345

2003

Cox, Liam R and DeBoos, Gareth A and Fullbrook, Jeremy J and Percy, Jonathan and Spencer, Neil S and Tolley, Malcolm (2003) Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose. Organic Letters, 5 (3). pp. 337-339. ISSN 1523-7060

Percy, J.M. and Hursthouse, M.B. and Spencer, N.S. and Tolley, M. and DiMartino, G. and Light, M.E. (2003) Syntheses of selectively fluorinated cyclodecenones: the first deployment of the neutral oxy-cope rearrangement in organofluorine chemistry. Organic and Biomolecular Chemistry, 1 (24). pp. 4423-4434. ISSN 1477-0520

2002

Crowley, Patrick J and Fawcett, John and Kariuki, Benson M and Moralee, Andrew C and Percy, Jonathan and Salafia, Vittoria (2002) Basic and reductive sulfone-directed ring-opening reactions of difluorinated oxa[2.2.1]bicycloheptanes. Organic Letters, 4 (23). pp. 4125-4128. ISSN 1523-7060

Kariuki, Benson M. and Owton, W. Martin and Percy, Jonathan and Pintat, Stephane and Smith, Clive A. and Spencer, Neil S and Thomas, Andrew C and Watson, Martin (2002) Rapid assembly of highly-functionalised difluorinated cyclooctenones via ring-closing metathesis. Chemical Communications, 2002 (3). pp. 228-229. ISSN 1359-7345

Butt, Afshan H and Kariuki, B M and Percy, Jonathan and Spencer, Neil S (2002) Towards stable analogues of inositol phosphates : stereoselective syntheses of (alpha,alpha-difluoromethyl)phosphonic acid (DFMPA)-containing cyclohexanes. Chemical Communications, 2002 (7). pp. 682-683. ISSN 1359-7345

2001

DeBoos, Gareth A and Fullbrook, Jeremy J and Percy, Jonathan (2001) Generating diversity in difluoromethyl ketone derivatives. Organic Letters, 3 (18). pp. 2859-2861. ISSN 1523-7060

Garayt, Maxime R and Percy, Jonathan (2001) A direct and useful route to difluoroacylsilanes and difluoroacylstannanes and their potential for the generation of structurally diverse difluoroketones. Tetrahedron Letters, 42 (36). pp. 6377-6380. ISSN 0040-4039

2000

Brown, Samantha J and Corr, Stuart and Percy, Jonathan (2000) Fluorinated succinic acid derivatives from new refrigerants via ozonolysis of haloalkenes. Tetrahedron Letters, 41 (27). pp. 5269-5273. ISSN 0040-4039

Kanai, M and Percy, Jonathan (2000) Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a. Tetrahedron Letters, 41 (14). 2453–2455. ISSN 0040-4039

Bainbridge, J Marie and Corr, Stuart and Kanai, Masatomi and Percy, Jonathan (2000) HFC-134a as a fluorinated building block : short syntheses of α-fluoroenones. Tetrahedron Letters, 41 (6). 971–974. ISSN 0040-4039

Cockerill, G Stuart and Easterfield, Howard J and Percy, Jonathan and Pintat, Stephanie (2000) Facile syntheses of building blocks for the construction of phosphotyrosine mimetics. Journal of the Chemical Society, Perkin Transactions 1, 2000 (16). pp. 2591-2599. ISSN 1472-7781

Crowley, P J and Moralee, A.C. and Percy, Jonathan and Spencer, N.S. (2000) Highly functionalised difluorinated cyclohexenols. Synlett, 2000 (12). pp. 1737-1740. ISSN 0936-5214

DeBoos, Gareth A. and Fullbrook, Jeremy J. and Owton, W. Martin and Percy, Jonathan and Thomas, Andrew C. (2000) Palladium-catalysed couplings of difluoroenol carbamate derivatives. Synlett, 2000 (7). pp. 963-966. ISSN 0936-5214

Percy, Jonathan and Pintat, Stephane (2000) Rapid syntheses of difluorinated dihydropyrans. Chemical Communications, 2000 (7). pp. 607-608. ISSN 1359-7345

Broadhurst, Michael and Brown, Samantha J and Percy, Jonathan and Prime, Michael E (2000) Synthesis of α-hydroxy-β,β-difluoro-γ-ketoesters via [3,3]sigmatropic rearrangements. Journal of the Chemical Society, Perkin Transactions 1, 2000 (19). pp. 3217-3226. ISSN 1472-7781

Butt, Afshan H and Percy, Jonathan and Spencer, Neil S (2000) A rearrangement-based approach to secondary difluorophosphonates. Chemical Communications, 2000 (17). pp. 1691-1692. ISSN 1359-7345

Dimartino, Gianluca and Percy, Jonathan (2000) An unusually rapid Claisen rearrangement involving ring expansion. Chemical Communications, 2000 (23). pp. 2339-2340. ISSN 1359-7345