Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose

Cox, Liam R and DeBoos, Gareth A and Fullbrook, Jeremy J and Percy, Jonathan and Spencer, Neil S and Tolley, Malcolm (2003) Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose. Organic Letters, 5 (3). pp. 337-339. ISSN 1523-7060 (https://doi.org/10.1021/ol02735)

Abstract

A new route, of potential strategic importance, to a difluorosugar analogue has been developed. Key steps included a Stille coupling and a highly regio- and enantioselective dihydroxylation of a highly substituted diene. Protecting groups were chosen to enhance the reactivity of the disubstituted allylic fragment in the AD reaction and allow deprotection under orthogonal conditions.

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• Item metadata

  Item type:	Article
  ID code:	38954
  Dates:	Date Event 6 February 2003 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	04 Apr 2012 14:00
  Last modified:	08 Apr 2024 19:53
  URI:	https://strathprints.strath.ac.uk/id/eprint/38954