Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose
Cox, Liam R and DeBoos, Gareth A and Fullbrook, Jeremy J and Percy, Jonathan and Spencer, Neil S and Tolley, Malcolm (2003) Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose. Organic Letters, 5 (3). pp. 337-339. ISSN 1523-7060 (https://doi.org/10.1021/ol02735)
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A new route, of potential strategic importance, to a difluorosugar analogue has been developed. Key steps included a Stille coupling and a highly regio- and enantioselective dihydroxylation of a highly substituted diene. Protecting groups were chosen to enhance the reactivity of the disubstituted allylic fragment in the AD reaction and allow deprotection under orthogonal conditions.
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Item type: Article ID code: 38954 Dates: DateEvent6 February 2003PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 04 Apr 2012 14:00 Last modified: 08 Apr 2024 19:53 URI: https://strathprints.strath.ac.uk/id/eprint/38954
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