Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose

Cox, Liam R and DeBoos, Gareth A and Fullbrook, Jeremy J and Percy, Jonathan and Spencer, Neil S and Tolley, Malcolm (2003) Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose. Organic Letters, 5 (3). pp. 337-339. ISSN 1523-7060 (https://doi.org/10.1021/ol02735)

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Abstract

A new route, of potential strategic importance, to a difluorosugar analogue has been developed. Key steps included a Stille coupling and a highly regio- and enantioselective dihydroxylation of a highly substituted diene. Protecting groups were chosen to enhance the reactivity of the disubstituted allylic fragment in the AD reaction and allow deprotection under orthogonal conditions.

ORCID iDs

Cox, Liam R, DeBoos, Gareth A, Fullbrook, Jeremy J, Percy, Jonathan ORCID logoORCID: https://orcid.org/0000-0001-8636-2704, Spencer, Neil S and Tolley, Malcolm;
CORE (COnnecting REpositories)