Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a
Kanai, M and Percy, Jonathan (2000) Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a. Tetrahedron Letters, 41 (14). 2453–2455. ISSN 0040-4039
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Abstract
Readily-available 1,1,1,2-tetrafluoroethane (Klea HFC-134a) can be converted, via a two-pot sequence into a range of Z--fluoroalkenoyl derivatives following addition reactions to aldehydes. Reaction adducts can be processed into enals and enones upon hydride reduction or Grignard reagent addition in high yield.
Creators(s): |
Kanai, M and Percy, Jonathan ![]() | Item type: | Article |
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ID code: | 38893 |
Keywords: | Z-α-fluoroalkenoyl, 1,1,1,2-tetrafluoroethane , hydride reduction, reagents, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 03 Apr 2012 13:04 |
Last modified: | 09 Sep 2020 00:48 |
URI: | https://strathprints.strath.ac.uk/id/eprint/38893 |
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