Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a

Kanai, M and Percy, Jonathan (2000) Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a. Tetrahedron Letters, 41 (14). 2453–2455. ISSN 0040-4039 (https://doi.org/10.1016/S0040-4039(00)00154-4)

Abstract

Readily-available 1,1,1,2-tetrafluoroethane (Klea HFC-134a) can be converted, via a two-pot sequence into a range of Z--fluoroalkenoyl derivatives following addition reactions to aldehydes. Reaction adducts can be processed into enals and enones upon hydride reduction or Grignard reagent addition in high yield.

ORCID iDs

Percy, Jonathan ORCID: https://orcid.org/0000-0001-8636-2704

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  Item type:	Article
  ID code:	38893
  Dates:	Date Event 1 April 2000 Published
  Keywords:	Z-α-fluoroalkenoyl, 1,1,1,2-tetrafluoroethane , hydride reduction, reagents, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	03 Apr 2012 13:04
  Last modified:	21 May 2023 03:18
  URI:	https://strathprints.strath.ac.uk/id/eprint/38893