Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a

Kanai, M and Percy, Jonathan (2000) Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a. Tetrahedron Letters, 41 (14). 2453–2455. ISSN 0040-4039

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Abstract

Readily-available 1,1,1,2-tetrafluoroethane (Klea HFC-134a) can be converted, via a two-pot sequence into a range of Z--fluoroalkenoyl derivatives following addition reactions to aldehydes. Reaction adducts can be processed into enals and enones upon hydride reduction or Grignard reagent addition in high yield.

Author(s):Kanai, M and Percy, Jonathan
Item type:Article
ID code:38893
Keywords:Z-α-fluoroalkenoyl, 1,1,1,2-tetrafluoroethane , hydride reduction, reagents, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery
Subjects:Science > Chemistry
Department:Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date deposited:03 Apr 2012 13:04
Last modified:28 Mar 2018 08:48
URI:https://strathprints.strath.ac.uk/id/eprint/38893
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