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Chin, Chiahsuan and Ravichandran, Ranjithkumar and Sanborn, Kristina and Fleming, Timothy and Wheatcroft, Stephen B and Kearney, Mark T and Tokman, Sofya and Walia, Rajat and Smith, Michael A and Flint, David J and Mohanakumar, Thalachallour and Bremner, Ross M and Sureshbabu, Angara (2023) Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis. Cell Reports Medicine, 4 (3). 100945.

John, Alison E. and Graves, Rebecca H. and Pun, Tao and Vitulli, Giovanni and Forty, Ellen J. and Mercer, Paul F. and Morrell, Josie L. and Barrett, John W. and Rogers, Rebecca F. and Hafeji, Maryam and Bibby, Lloyd I. and Gower, Elaine and Morrison, Valerie S. and Man, Yim and Roper, James A. and Luckett, Jeni C. and Borthwick, Lee A. and Barksby, Ben S. and Burgoyne, Rachel A. and Barnes, Rory and Le, Joelle and Flint, David J. and Pyne, Susan and Habgood, Anthony and Organ, Louise A. and Joseph, Chitra and Edwards-Pritchard, Rochelle C. and Maher, Toby M. and Fisher, Andrew J. and Gudmann, Natasja Staehr and Leeming, Diana J. and Chambers, Rachel C. and Lukey, Pauline T. and Marshall, Richard P. and Macdonald, Simon J. F. and Jenkins, Gisli and Slack, Robert J. (2020) Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis. Nature Communications, 11 (1). 4659. ISSN 2041-1723

Mulholland, Theresa and McAllister, Milly and Patek, Samantha and Flint, David and Underwood, Mark and Sim, Alexander and Edwards, Joanne and Zagnoni, Michele (2018) Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient. Scientific Reports, 8. 14672. ISSN 2045-2322

Mulholland, Theresa E. and McAllister, Milly and Patek, Samantha and Flint, David and Underwood, Mark and Sim, Alexander and Edwards, Joanne and Zagnoni, Michele (2018) Drug screening of biopsy-derived multicellular spheroids using microfluidic technology. Cancer Research, 78 (13 (su). 5024. ISSN 0008-5472

Slack, Robert J. and Hafeji, Maryam and Rogers, Rebecca and Ludbrook, Steve B. and Marshall, John F. and Flint, David J. and Pyne, Susan and Denyer, Jane C. (2016) Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2. Pharmacology, 97 (3-4). pp. 114-125. ISSN 1423-0313

Wright, Catherine S and Berends, Rebecca F and Flint, David J and Martin, Patricia E M (2013) Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5. Experimental Cell Research, 319 (4). pp. 390-401.

Nakatani, Hajime and Yasueda, Takehiko and Oshima, Kenzi and Okajima, Tetsuya and Nadano, Daita and Flint, David J and Matsuda, Tsukasa (2013) Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells. Journal of Biochemistry, 153 (1). pp. 31-41.

Vijayan, A and Guha, D and Fasal, A and Kaziri, I and Mooney, C C and Bennett, L and Sureshbabu, A and Tonner, E and Beattie, J and Edwards, J and Flint, D J (2013) IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion. International Journal of Biochemistry and Cell Biology, 45 (12). pp. 2774-2785.

Sureshbabu, A and Okajima, H and Yamanaka, D and Tonner, E and Shastri, S and Maycock, J and Szymanowska, M and Shand, J and Takahashi, S-I and Beattie, J and Allan, G J and Flint, David (2012) IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells. Journal of Cell Science, 125 (7). pp. 1693-1705.

Wright, Catherine S and Pollok, Simone and Flint, David J and Brandner, Johanna M and Martin, Patricia E M (2012) The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro. Journal of Cellular Physiology, 227 (1). pp. 77-87.

Large, Emma and Pryde, Anne and Plevris, John and Flint, David and Grant, Mary (2011) Insulin-like growth factor binding protein-5 as a biomarker for detection of early liver disease. Toxicology, 290 (2-3). p. 124. ISSN 0300-483X

Kirkpatrick, Gordon J and Plumb, Jane A and Sutcliffe, Oliver B and Flint, David J and Wheate, Nial J (2011) Evaluation of anionic half generation 3.5-6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin. Journal of Inorganic Biochemistry, 105 (9). pp. 1115-1122.

Large, Emma and Henderson, Catherine and Flint, David and Grant, Mary (2011) IGFBP-5 as a biomarker of de-differentiation in hepatocytes. Toxicology Letters, 205 (Supple). S65-S65. ISSN 0378-4274

Laco, F. and Grant, M.H. and Flint, D.J. and Black, R.A. (2011) Cellular trans-differentiation and morphogenesis towards the lymphatic lineage in regenerative medicine. Stem Cells and Development, 20 (2). pp. 181-195. ISSN 1547-3287

Sureshbabu, Angara and Tonner, Elizabeth and Flint, David J (2011) Insulin-like growth factor binding proteins and mammary gland development. International Journal of Developmental Biology, 55 (7-9). pp. 781-9.

Sureshbabu, A. and Tonner, E. and Allan, G. J. and Flint, D. J. (2011) Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis. Pulmonary Medicine, 2011. 517687.

Large, E. and Henderson, C.J. and Flint, D.J. and Grant, M.H. (2010) Oxidative stress via hydrogen peroxide and menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes. Toxicology, 278 (3). pp. 356-357. ISSN 0300-483X

Brown, Sarah D. and Nativo, Paola and Smith, Jo-Ann and Stirling, David and Edwards, Paul R. and Venugopal, Balaji and Flint, David J. and Plumb, Jane A. and Graham, Duncan and Wheate, Nial J. (2010) Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. Journal of the American Chemical Society, 132 (13). pp. 4678-4684. ISSN 1520-5126

Nakatani, Hajime and Aoki, Naohito and Okajima, Tetsuya and Nadano, Daita and Flint, D.J. and Matsuda, Tsukasa (2010) Establishment of a mammary stromal fibroblastic cell line for in vitro studies in mice of mammary adipocyte differentiation. Biology of Reproduction, 82 (1). pp. 44-53. ISSN 0006-3363

Wright, C.S. and Flint, D.J. and Martin, P.E. (2009) Connexin mimetic peptides increase cell migration in scrape-wounded human organotypic skin models and alter gene expression of dermal fibroblasts. Journal of Investigative Dermatology, 129 (S1-S10). S81-S81. 485. ISSN 0022-202X

Sureshbabu, Angara and Okajima, Hiroshi and Yamanaka, Daisuke and Shastri, Surya and Tonner, Elizabeth and Rae, Colin and Szymanowska, M. and Shand, J.H. and Takahashi, Shin-Ichiro and Beattie, J. and Allan, G.J. and Flint, D.J. (2009) IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response. Biochemical Society Transactions, 37. pp. 882-885. ISSN 0300-5127

Beattie, James and Kreiner, M. and Allan, G.J. and Flint, D.J. and Domingues, Diana and van der Walle, Christopher F. (2009) IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin. Biochemical and Biophysical Research Communications, 381 (4). pp. 572-576. ISSN 1090-2104

Whitton, A. and Black, R.A. and Flint, D.J. (2009) Development of a cell population migration assay. European Cells and Materials, 18 (Suppl.). p. 110. ISSN 1473-2262

Whitton, A. and Flint, D.J. and Black, R.A. (2009) Differential effect of substrate stiffness and adsorbed fibronectin density on vascular smooth muscle migration rate. European Cells and Materials, 18 (Suppl.). p. 29. ISSN 1473-2262

Flint, D.J. and Tonner, E. and Beattie, J. and Allan, G.J. (2008) Role of insulin-like growth factor binding proteins in mammary gland development. Journal of Mammary Gland Biology and Neoplasia, 13 (4). pp. 443-453. ISSN 1083-3021

Allan, G.J. and Beattie, J. and Flint, D.J. (2008) Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving igf-binding protein-5. Journal of Endocrinology, 199 (2). pp. 155-164. ISSN 0022-0795

Hill, Rodney A. and Flint, D.J. and Pell, Jenifer M. (2008) Antibodies as molecular mimics of biomolecules: roles in understanding physiological functions and mechanisms. Advances in Physiology Education, 32. pp. 261-273. ISSN 1043-4046

Allan, G.J. and Beattie, J. and Shand, J.H. and Szymanowska, M. and Flint, D.J. (2008) Molecular interactions in the insulin-like growth factor (IGF) axis: a surface plasmon resonance (SPR) based biosensor study. Molecular and Cellular Biochemistry, 307 (1-2). pp. 221-236. ISSN 0300-8177

Flint, D.J. (2007) Mammary gland involution and endocrine status in sows: effects of weaning age and lactation heat stress. Canadian Journal of Animal Science, 87. pp. 35-43. ISSN 0008-3984

Sorrell, A.M. and Shand, J.H. and Tonner, E. and Gamberoni, M. and Accorsi, P.A. and Beattie, J. and Allan, G.J. and Flint, D.J. (2006) Insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin. Journal of Biological Chemistry, 281 (16). pp. 10883-10889. ISSN 1083-351X

Lochrie, J.D. and Phillips, K. and Tonner, E. and Flint, D.J. and Allan, G.J. and Price, N. and Beattie, J. (2006) Insulin-like growth factor binding protein (IGFBP)-5 Is upregulated during both differentiation and apoptosis in primary cultures of mouse mammary epithelial cells. Journal of Cellular Physiology, 207. pp. 471-479. ISSN 0021-9541

Beattie, James and Allan, Gordon J. and Lochrie, Jennifer D. and Flint, David J. (2006) Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochemical Journal, 395. pp. 1-19. ISSN 0264-6021

Flint, D.J. and Boutinaud, M. and Whitelaw, C.B.A. and Allan, G.J. and Kolb, A.F. (2006) Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mammary gland but fails to prevent cell loss in the mammary glands of mice expressing iGFBP-5 as a mammary transgene. Journal of Molecular Endocrinology, 36. pp. 435-448. ISSN 0952-5041

Flint, David J. and Travers, Maureen T. and Barber, Michael C. and Binart, Nadine and Kelly, Paul A. (2005) Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland. American Journal of Physiology - Endocrinology and Metabolism, 288 (6). E1179-E1187. ISSN 0193-1849

Allan, G.J. and Tonner, E. and Szymanowska, M. and Shand, J. and Kelly, S.M. and Phillips, K. and Clegg, R.A. and Gow, I.F. and Beattie, J. and Flint, D.J. (2005) Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action. Endocrinology, 147 (1). pp. 338-349. ISSN 0013-7227

Beattie, J. and Phillips, K. and Shand, J. and Szymanowska, M. and Flint, D.J. and Allan, G.J. (2005) Molecular recognition characteristics in the insulin-like growth factor (IGF)-insulin-like growth factor binding protein-3/5 (IGFBP-3/5) heparin axis. Journal of Molecular Endocrinology, 34. pp. 163-175. ISSN 0952-5041

Boutinaud, M. and Shand, J.H. and Beattie, J. and Park, M. and Allan, G.J. and Phillips, K. and Flint, D.J. (2004) A quantitative RT-PCR study of the mRNA expression profile of the IGF axis during mammary gland development. Journal of Molecular Endocrinology, 33 (1). pp. 195-207. ISSN 0952-5041

Phillips, K. and Park, M.A. and Quarrie, L.H. and Boutinaud, M. and Lochrie, J.D. and Flint, D.J. and Allan, G.J. and Beattie, J. (2003) Hormonal control of IGF-binding protein (IGFBP)-5 and IGFBP-2 secretion during differentiation of the HC11 mouse mammary epithelial cell line. Journal of Molecular Endocrinology, 31 (1). pp. 197-208. ISSN 0952-5041

Shand, J.H. and Beattie, J. and Flint, D.J. and Song, H. and Allan, G.J. and Phillips, K. and Kelly, S.M. (2003) Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I. Journal of Biological Chemistry, 278 (20). pp. 17859-17866. ISSN 1083-351X

Marshman, E. and Green, K.A. and Flint, D.J. and White, A. and Streuli, C.H. and Westwood, M. (2003) Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells. Journal of Cell Science, 116. pp. 675-682. ISSN 0021-9533

Allan, G.J. and Tonner, E. and Barber, M.C. and Travers, M. and Shand, J. and Vernon, R.G. and Kelly, P.A. and Binart, N. and Flint, D.J. (2002) Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental but not metabolic activity in the mammary gland of mice expressing a single allele of the prolactin receptor. Endocrinology, 143 (11). pp. 4310-4319. ISSN 0013-7227

Tonner, Elizabeth and Barber, Michael C. and Allan, Gordon J. and Beattie, James and Webster, John and Whitelaw, C. Bruce and Flint, David J. (2002) Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice. Development, 129. pp. 4547-4557. ISSN 0950-1991

Conference or Workshop Item

Large, Emma and Henderson, Catherine and Flint, David and Grant, Mary (2011) IGFBP-5 and hepatocyte differentiation. In: 40th Anniversary DMDG Meeting, 2011-08-11 - 2011-08-12. (Unpublished)

Laco, F. and Grant, M.H. and Flint, D.J. and Black, R.A. (2010) Electrospun 3D Scaffolds for Lymphatic Tissue Engineering. In: Gordon Research Conference for Molecular Mechanisms in Lymphatic Function & Disease, 2010-06-13 - 2010-06-18.

Kirkpatrick, G.J. and Sutcliffe, O.B. and Flint, D.J. and Wheate, N.J. (2009) PAMAM dendrimers as drug delivery vehicles for platinum anticancer drugs. In: Gordon Research Conference: Metals in Medicine, 2009-06-28 - 2009-07-02.