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Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis

Sureshbabu, A. and Tonner, E. and Allan, G. J. and Flint, D. J. (2011) Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis. Pulmonary Medicine, 2011.

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Abstract

Although most evident in the skin, the process of scarring, or fibrosis, occurs in all major organs because of impaired epithelial self-renewal. No current therapy exists for Idiopathic pulmonary fibrosis. The major profibrotic factor is TGF-β1 and developing inhibitors is an area of active research. Recently, IGFBP-5 has also been identified as a profibrotic factor, and studies suggest that, while both TGF-β1 and IGFBP-5 activate mesenchymal cells to increase collagen and fibronectin production, their effects on epithelial cells are distinct. TGF-β1 induces cell death and/or EMT in the epithelial cells, exacerbating the disruption of tissue architecture. In contrast, IGFBP-5 induces epithelial cell spreading over collagen or fibronectin matrices, increases secretion of laminin, the epithelial basement membrane, and enhances the survival of epithelial cells in nutrient-poor conditions, as exists in scar tissue. Thus, IGFBP-5 may enhance repair and may be an important target for antifibrotic therapies.

Item type: Article
ID code: 42415
Keywords: scarring, fibrosis, epithelial self-renewal, pulmonary fibrosis, TGF-β1, IGFBP-5, idiopathic pulmonary fibrosis, Pharmacy and materia medica, Pulmonary and Respiratory Medicine
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited: 19 Dec 2012 11:41
Last modified: 05 Jan 2019 02:45
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URI: https://strathprints.strath.ac.uk/id/eprint/42415
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