Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis

Sureshbabu, A. and Tonner, E. and Allan, G. J. and Flint, D. J. (2011) Relative roles of TGF-β and IGFBP-5 in idiopathic pulmonary fibrosis. Pulmonary Medicine, 2011.

[img]
Preview
Text (Sureshbabu-etal-PM2011-Relative-roles-of-TGF-β-and-IGFBP-5-in-idiopathic)
Sureshbabu_etal_PM2011_Relative_roles_of_TGF_and_IGFBP_5_in_idiopathic.pdf
Final Published Version
License: Creative Commons Attribution 3.0 logo

Download (1MB) | Preview

Abstract

Although most evident in the skin, the process of scarring, or fibrosis, occurs in all major organs because of impaired epithelial self-renewal. No current therapy exists for Idiopathic pulmonary fibrosis. The major profibrotic factor is TGF-β1 and developing inhibitors is an area of active research. Recently, IGFBP-5 has also been identified as a profibrotic factor, and studies suggest that, while both TGF-β1 and IGFBP-5 activate mesenchymal cells to increase collagen and fibronectin production, their effects on epithelial cells are distinct. TGF-β1 induces cell death and/or EMT in the epithelial cells, exacerbating the disruption of tissue architecture. In contrast, IGFBP-5 induces epithelial cell spreading over collagen or fibronectin matrices, increases secretion of laminin, the epithelial basement membrane, and enhances the survival of epithelial cells in nutrient-poor conditions, as exists in scar tissue. Thus, IGFBP-5 may enhance repair and may be an important target for antifibrotic therapies.