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2024

McKinnon, Zoe and Khadra, Ibrahim and Halbert, Gavin W. and Batchelor, Hannah K. (2024) Characterisation of colloidal structures and their solubilising potential for BCS class II drugs in fasted state simulated intestinal fluid. International Journal of Pharmaceutics, 665. 124733. ISSN 1873-3476

Obeid, Mohammad A. and Akil, Lina and Abul-Haija, Yousef M. and Khadra, Ibrahim (2024) Formulation of polycaprolactone meshes by melt electrospinning for controlled release of daunorubicin in tumour therapy. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 699. 134873. ISSN 0927-7757

Fardous, Roa S. and Alshmmari, Sultan and Tawfik, Essam and Khadra, Ibrahim and Ramadan, Qasem and Zourob, Moahammed (2024) An integrated and modular compartmentalized microfluidic system with tunable electrospun porous membranes for epithelialized organs-on-a-chip. ACS Applied Materials and Interfaces, 16 (31). pp. 40767-40786. ISSN 1944-8252

Ibrahim, Areen and Odeh, Mohanad and Mallah, Eyad and Abu-Qatouseh, Luay and Awaad, Ahmad Abu and Ahmad, Mohammad I. A. and Shdifat, Amjad and Saleh, Soadad and Al Hyari, Muwafaq and Khadra, Ibrahim and Omari, Khaled W. and Arafat, Tawfiq (2024) Genetic analysis : therapeutic drug monitoring of metformin and glimepiride on diabetic patients’ plasma including genetic polymorphism. Journal of Advanced Pharmaceutical Technology & Research, 15 (3). pp. 150-155. ISSN 0976-2094

Abuhassan, Qamar and Silva, Maria Inês and Abu-Rajab Tamimi, Rana and Khadra, Ibrahim and Batchelor, Hannah K. and Pyper, Kate and Halbert, Gavin W. (2024) A novel simulated media system for in vitro evaluation of bioequivalent intestinal drug solubility. European Journal of Pharmaceutics and Biopharmaceutics, 199. 114302. ISSN 0939-6411

Obeid, Mohammad A. and Akil, Lina and A Aljabali, Alaa and Khadra, Ibrahim (2024) Characterization of ciprofloxacin-loaded polymeric fiber mats prepared by meltelectrospinning. Macromolecular Materials and Engineering, 309 (4). 2300376. ISSN 1439-2054

2023

Silva, Maria Inês and Khadra, Ibrahim and Pyper, Kate and Halbert, Gavin W. (2023) Structured solubility behaviour in fed simulated intestinal fluids. European Journal of Pharmaceutics and Biopharmaceutics, 193. pp. 58-73. ISSN 0939-6411

McKinnon, Zoe and Batchelor, Hannah and Khadra, Ibrahim and Halbert, Gavin (2023) Study of in vitro poorly soluble drug solubility into fasted state simulated intestinal fluid reflective of in vivo gastrointestinal variability. British Journal of Pharmacy, 8 (2). 1380. ISSN 2058-8356

Obeid, Mohammad A. and Haifawi, Saja and Khadra, Ibrahim (2023) The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing. International Journal of Pharmaceutics: X, 5. 100168. ISSN 2590-1567

Ainousah, Bayan E. and Khadra, Ibrahim and Halbert, Gavin W. (2023) Excipients impact on fenofibrate equilibrium solubility in fasted and fed simulated intestinal fluids assessed using a design of experiment protocol. Pharmaceutics, 15 (10). 2484. ISSN 1999-4923

Silva, Maria Inês and Khadra, Ibrahim and Pyper, Kate and Halbert, Gavin W. (2023) Fed intestinal solubility limits and distributions applied to the developability classification system. European Journal of Pharmaceutics and Biopharmaceutics, 186. pp. 74-84. ISSN 0939-6411

El-Nashar, Heba A. S. and Sayed, Ahmed M. and El-Sherief, Hany A. M. and Rateb, Mostafa E. and Akil, Lina and Khadra, Ibrahim and Majrashi, Taghreed A. and Al-Rashood, Sara T. and Binjubair, Faizah A. and El Hassab, Mahmoud A. and Eldehna, Wagdy M. and Abdelmohsen, Usama Ramadan and Mostafa, Nada M. (2023) Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia. Journal of Enzyme Inhibition and Medicinal Chemistry, 38 (1). 2199950. ISSN 1475-6374

Halbert, Gavin and Inês Silva, Maria and Abuhassan, Qamar and Khadra, Ibrahim and Pyper, Kate and Augustijns, Patrick and Brouwer, Joachim (2023) Acidic drugs - intestinal solubility correlation fasted and fed in vitro vs ex vivo. In: 4th European Conference on Pharmaceutics, 2023-03-20 - 2023-03-21, Palais des Congrés.

Alghamdi, Adel and Abouzied, Amr S. and Alamri, Abdulwahab and Anwar, Sirajudheen and Ansari, Mukhtar and Khadra, Ibrahim and Zaki, Yasser H. and Gomha, Sobhi M. (2023) Synthesis, molecular docking, and dynamic simulation targeting main protease (Mpro) of new, Thiazole clubbed pyridine scaffolds as potential COVID-19 inhibitors. Current Issues in Molecular Biology, 45 (2). pp. 1422-1442. ISSN 1467-3045

Maclean, Natalie and Khadra, Ibrahim and Mann, James and Abbott, Alexander and Mead, Heather and Markl, Daniel (2023) Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed griseofulvin tablets. International Journal of Pharmaceutics, 631. 122473. ISSN 1873-3476

Hassan, Hind Ashraf and Abdelhafez, Omnia Hesham and Shady, Nourhan Hisham and Yahia, Ramadan and Mohamed, Nada M. and Rateb, Mostafa E. and Akil, Lina and Khadra, Ibrahim and Glaeser, Stefanie P. and Kämpfer, Peter and Abdelmohsen, Usama Ramadan and El-Katatny, Mo'men Hamed (2023) The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies. Natural Product Research, 37 (23). pp. 4063-4068. ISSN 1478-6427

2022

Obeid, Mohammad A. and Khadra, Ibrahim and A.A. Aljabali, Alaa and Amawi, Haneen and Ferro, Valerie A. (2022) Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery. International Journal of Pharmaceutics: X, 4. 100137. ISSN 2590-1567

Ahmed, Shereen Sayed Taha and Fahim, John Refaat and Youssif, Khayrya A. and Amin, Mohamed N. and Abdel-Aziz, Hossam M.H. and Khadra, Ibrahim A. and Rateb, Mostafa E. and Abdelmohsen, Usama Ramadan and Hamed, Ashraf Nageeb Elsayed (2022) Comparative study of the chemical composition and anti-proliferative activities of the aerial parts and roots of Apium graveolens L. (celery) and their biogenic nanoparticles. South African Journal of Botany, 151. pp. 34-45. ISSN 0254-6299

McKinnon, Zoe and Batchelor, Hannah and Khadra, Ibrahim and Halbert, Gavin (2022) Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid. British Journal of Pharmacy, 7 (2). ISSN 2058-8356

Silva, Maria Inês and Khadra, Ibrahim and Pyper, Kate and Halbert, Gavin W. (2022) Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid. European Journal of Pharmaceutics and Biopharmaceutics, 177. pp. 126-134. ISSN 0939-6411

Abuhassan, Qamar and Khadra, Ibrahim and Pyper, Kate and Augustijns, Patrick and Brouwers, Joachim and Halbert, Gavin W. (2022) Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids. European Journal of Pharmaceutics and Biopharmaceutics, 176. pp. 108-121. ISSN 0939-6411

Jesney, H. and Khadra, I. and Mann, J. and Barker, R. and Markl, D. (2022) Multi-modal dissolution testing system for pharmaceutical tablets. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Abuhassan, Qamar and Khadra, Ibrahim and Pyper, Kate and Augustijns, Patrick and Brouwers, Joachim and Halbert, Gavin W. (2022) Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems. European Journal of Pharmaceutics and Biopharmaceutics, 170. pp. 160-169. ISSN 0939-6411

2021

Maclean, Natalie and Khadra, Ibrahim and Mann, James and Williams, Helen and Abbott, Alexander and Mead, Heather and Markl, Daniel (2021) Investigating the role of excipients on the physical stability of directly compressed tablets. International Journal of Pharmaceutics: X, 4 (Dec 20). 100106. ISSN 2590-1567

Abuhassan, Qamar and Khadra, Ibrahim and Pyper, Kate and Halbert, Gavin W. (2021) Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid. European Journal of Pharmaceutics and Biopharmaceutics, 168. pp. 90-96. ISSN 0939-6411

Abuhassan, Qamar and Silva, Maria and Khadra, Ibrahim and Halbert, Gavin and Pyper, Kate and Brouwers, Joachim (2021) Bioequivalent Simulated Intestinal Fluid - The first segment. In: UnGap Annual Conference, 2021-09-28 - 2021-09-29, KU Leuven.

Markl, Daniel and Maclean, Natalie and Mann, James and Williams, Helen and Abbott, Alexander and Mead, Heather and Khadra, Ibrahim (2021) Tablet disintegration performance : effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics. International Journal of Pharmaceutics, 601. 120382. ISSN 1873-3476

Maclean, Natalie and Walsh, Erin and Soundaranathan, Mithushan and Khadra, Ibrahim and Mann, James and Williams, Helen and Markl, Daniel (2021) Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations. International Journal of Pharmaceutics, 599. 120221. ISSN 1873-3476

2020

Hanna, Catherine R. and Blyth, Kevin G. and Burley, Glenn and Carmichael, Samantha and Evans, Carol and Hinsley, Samantha and Khadra, Ibrahim and Khoo, Saye and Lewsley, Liz-Anne and Jones, Robert R. and Sharma, Raman and Taladriz-Sender, Andrea and Thomson, Emma C. and Scott, Janet T. (2020) Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19 : a structured summary of a study protocol for a randomised controlled trial. Trials, 21. 935. ISSN 1745-6215

Pyper, Kate and Brouwers, Joachim and Augustijns, Patrick and Khadra, I. and Dunn, C. and Wilson, C.G. and Halbert, G.W. (2020) Multidimensional analysis of human intestinal fluid composition. European Journal of Pharmaceutics and Biopharmaceutics, 153. pp. 226-240. ISSN 0939-6411

McPherson, Stephanie and Perrier, Jeremy and Dunn, Claire and Khadra, Ibrahim and Davidson, Scott and Ainousah, Bayan and Wilson, Clive G. and Halbert, Gavin (2020) Small scale design of experiment investigation of equilibrium solubility in simulated fasted and fed intestinal fluid. European Journal of Pharmaceutics and Biopharmaceutics, 150. pp. 14-23. ISSN 0939-6411

Etherson, Kelly and Dunn, Claire and Matthews, Wayne and Pamelund, Henrik and Barragat, Camille and Sanderson, Natalie and Izumi, Toshiko and da Costa Mathews, Claudia and Halbert, Gavin and Wilson, Clive and McAllister, Mark and Mann, James and Østergaard, Jesper and Butler, James and Khadra, Ibrahim (2020) An interlaboratory investigation of intrinsic dissolution rate determination using surface dissolution. European Journal of Pharmaceutics and Biopharmaceutics, 150. pp. 24-32. ISSN 0939-6411

2019

Obeid, Mohammad A. and Khadra, Ibrahim and Albaloushi, Abdullah and Mullin, Margaret and Alyamani, Hanin and Ferro, Valerie A. (2019) Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation : physical characteristics, encapsulation efficacy, and drug release. Beilstein Journal of Nanotechnology, 10. pp. 1826-1832. ISSN 2190-4286

Dunn, Claire and Perrier, Jeremy and Khadra, Ibrahim and Wilson, Clive G. and Halbert, Gavin W. (2019) The topography of simulated intestinal equilibrium solubility. Molecular Pharmaceutics, 16 (5). pp. 1890-1905. ISSN 1543-8384

Khadra, Ibrahim and Obeid, Mohammad A. and Dunn, Claire and Watts, Stewart and Halbert, Gavin and Ford, Steven and Mullen, Alexander (2019) Characterisation and optimisation of diclofenac sodium orodispersible thin film formulation. International Journal of Pharmaceutics, 561. pp. 43-46. ISSN 1873-3476

Khan, Amjad and Iqbal, Zafar and Ullah, Aman and Khadra, Ibrahim and Sherazi, Mehrin and Zeb, Noreen (2019) Discriminatory dissolution testing for liquisolid compacts containing a poorly water-soluble drug (Hydrochlorothiazide). Dissolution Technologies, 26 (1). pp. 46-54. ISSN 1521-298X

Al-Tannak, N.F. and Khadra, Ibrahim and Igoli, N.P. and Igoli, J.O. (2019) LC-MS analysis of oils of Monodora myristica and Monodora tenuifolia and isolation of a novel cyclopropane fatty acid. Natural Product Research. ISSN 1478-6427

2018

Halbert, Gavin and Dunn, Claire and Khadra, Ibrahim and Wilson, Clive (2018) Equilibrium solubility in simulated intestinal media. In: "5 Years of progress in Oral Biopharmaceutics - IMI OrBiTo project and global biopharmaceutics research", 2018-09-17 - 2018-09-18, AstraZeneca, Granta Park.

Perrier, Jeremy and Zhou, Zhou and Dunn, Claire and Khadra, Ibrahim and Wilson, Clive G. and Halbert, Gavin (2018) Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs. European Journal of Pharmaceutical Sciences, 111. pp. 247-256. ISSN 0928-0987

2017

Ainousah, Bayan E and Perrier, Jeremy and Dunn, Claire and Khadra, Ibrahim and Wilson, Clive G. and Halbert, Gavin W (2017) Dual level statistical investigation of equilibrium solubility in simulated fasted and fed intestinal fluid. Molecular Pharmaceutics, 14 (12). pp. 4170-4180. ISSN 1543-8384

Ullah, Aman and Iqbal, Zafar and Shah, Yasar and Ahmad, Lateef and Khuda, Fazle and Ullah, Zia and Hassan, Muhammad and Ismail and Shahbaz, Naila and Khadra, Ibrahim (2017) Validated and optimized RP-HPLC method for the simultaneous quantification of meloxicam and its major metabolites in biological fluids with liquid liquid and solid phase extraction technique. Journal of the Chemical Society of Pakistan, 39 (5). pp. 802-811. ISSN 0253-5106

Zhou, Zhou and Dunn, Claire and Khadra, Ibrahim and Wilson, Clive G. and Halbert, Gavin W. (2017) Influence of physiological gastrointestinal surfactant ratio on the equilibrium solubility of BCS class II drugs investigated using a four component mixture design. Molecular Pharmaceutics. ISSN 1543-8384

Abualhasan, Murad N and Mansour, Jumana and Jaradat, Nidal and Zaid, Abdel Naser and Khadra, Ibrahim (2017) Formulation and development of a validated UV-spectrophotometric analytical method of Rutin tablet. International Scholarly Research Notices, 2017. 2624947. ISSN 2356-7872

Zhou, Zhou and Dunn, Claire and Khadra, Ibrahim and Wilson, Clive G. and Halbert, Gavin W. (2017) Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs. European Journal of Pharmaceutical Sciences, 99. pp. 95-104. ISSN 0928-0987

García Fernández-Luna, Veronica and Mallinson, D. and Alexiou, P. and Khadra, I. and Mullen, A. B. and Pelecanou, M. and Sagnou, M. and Lamprou, D. A. (2017) Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films : concentration effect and release studies. RSC Advances, 7. 12945 - 12952. ISSN 2046-2069

Obeid, Mohammad A. and Khadra, Ibrahim and Mullen, Alexander B. and Tate, Rothwelle J. and Ferro, Valerie A. (2017) The effects of hydration media on the characteristics of non-ionic surfactant vesicles (NISV) prepared by microfluidics. International Journal of Pharmaceutics, 516 (1-2). pp. 52-60. ISSN 1873-3476

2016

Kourentas, Alexandros and Vertzoni, Maria and Khadra, Ibrahim and Symillides, Mira and Clark, Hugh and Halbert, Gavin and Butler, James and Reppas, Christos (2016) Evaluation of the impact of excipients and an albendazole salt on albendazole concentrations in upper small intestine using an in vitro biorelevant gastrointestinal transfer (BioGIT) system. Journal of Pharmaceutical Sciences, 105 (9). pp. 2896-2903. ISSN 0022-3549

Khan, Amjad and Iqbal, Zafar and Khadra, Ibrahim and Ahmad, Lateef and Khan, Abad and Khan, Muhammad Imran and Ullah, Zia and Ismail (2016) Simultaneous determination of domperidone and Itopride in pharmaceuticals and human plasma using RP-HPLC/UV detection : method development, validation and application of the method in in-vivo evaluation of fast dispersible tablets. Journal of Pharmaceutical and Biomedical Analysis, 121. pp. 6-12. ISSN 1873-264X

2014

Kourentas, A and Vertzoni, M and Khadra, Ibrahim and Halbert, Gavin and Clark, Hugh and Butler, James and Reppas, Christos (2014) Albendazole vs. albendazole sulphate in the fasted upper gastrointestinal lumen based on ex vivo and in vitro data. In: American Association of Pharmaceutical Scientists, 2014-11-02 - 2014-11-06, San Diego.

2008

Zhang, Tong and Khadra, Ibrahim and Euerby, Melvin R. and Skellern, G.G. and Watson, David G. and Tettey, J.N.A. (2008) Simultaneous analysis of basic, acidic and neutral compounds on an endcapped octadecylsilane silica-based monolith by pressure-assisted capillary electrochromatography. Electrophoresis, 29 (4). pp. 944-951. ISSN 0173-0835