Characterisation of ciprofloxacin-loaded polymeric fiber mats prepared by meltelectrospinning

Obeid, Mohammad A. and Akil, Lina and A Aljabali, Alaa and Khadra, Ibrahim (2023) Characterisation of ciprofloxacin-loaded polymeric fiber mats prepared by meltelectrospinning. Macromolecular Materials and Engineering, 309 (4). 2300376. ISSN 1439-2054 (https://doi.org/10.1002/mame.202300376)

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Abstract

Electrospun drug-loaded polymers are used to make formulations that slowly release medication. This study creates ciprofloxacin (Cip)-loaded fiber mats by melt electrospinning using polycaprolactone (PCL) and PEG4000 for controlled release of Cip. The increase in Cip concentration and PEG4000 percentages increases the mat thickness resulting in uniform morphology. The tensile strength of the PCL mat is significantly improved by adding higher concentrations of Cip while PEG inclusion reduced the tensile strength significantly. Differential Scanning Calorimetry (DSC) curves of PCL and PEG 4000 either as free components of after melt electrospinning are identical and both components shows a single endothermic peak at 63 and 61 °C respectively. Fourier transform infrared spectroscopy confirms the chemical stability of the raw materials, while X-ray diffraction shows the conversion of PEG and Cip from crystalline to amorphous structure following melt electrospinning. Cip is released gradually over 72 h, and the release is increased in the presence of PEG with a maximum Cip release ≈25% after 72 h. The study provides new insights into the development of controlled release fiber mats loaded with antibacterial agents. This can help to develop formulations for wound dressings that improve the clinical outcomes.

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