Browse by Author or creator

Doonan, James and Thomas, David and Wong, Michelle H. and Ramage, Hazel J. and Al-Riyami, Lamyaa and Lumb, Felicity E. and Bell, Kara S. and Fairlie-Clarke, Karen J. and Suckling, Colin J. and Michelsen, Kathrin S. and Jiang, Hui-Rong and Cooke, Anne and Harnett, Margaret M. and Harnett, William (2018) Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease. Molecules, 23 (10). 2669. ISSN 1420-3049

Ball, Dimity H. and Al-Riyami, Lamyaa and Harnett, William and Harnett, Margaret M. (2018) IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62. Scientific Reports, 8 (1). pp. 1-15. 4497. ISSN 2045-2322

Ahmed, Umul Kulthum and Maller, N. Claire and Iqbal, Asif J. and Al-Riyami, Lamyaa and Harnett, William and Raynes, John G. (2016) The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation. Journal of Biological Chemistry, 291 (22). pp. 11939-11953. ISSN 1083-351X

Coltherd, J. C. and Rodgers, D. T. and Lawrie, R. E. and Al-Riyami, L. and Suckling, C. J. and Harnett, W. and Harnett, M. M. (2016) The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma. Scientific Reports, 6. 19224. ISSN 2045-2322

Rzepecka, Justyna and Pineda, Miguel A. and Al-Riyami, Lamyaa and Rodgers, David T. and Huggan, Judith K. and Lumb, Felicity E. and Khalaf, Abedawn I. and Meakin, Paul J. and Corbet, Marlene and Ashford, Michael L. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60. pp. 59-73. ISSN 0896-8411

Rodgers, David T. and McGrath, Mairi A. and Pineda, Miguel A. and Al-Riyami, Lamyaa and Rzepecka, Justyna and Lumb, Felicity and Harnett, William and Harnett, Margaret M. (2015) The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice. Arthritis and Rheumatology, 67 (4). pp. 1023-1035. ISSN 2326-5205

Al-Riyami, Lamyaa and Rodgers, David T. and Rzepecka, Justyna and Pineda, Miguel A. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2015) Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation. Experimental Parasitology. ISSN 0014-4894 (In Press)

Aprahamian, Tamar R. and Zhong, Xuemei and Amir, Shahzada and Binder, Christoph J. and Chiang, Lo-Ku and Al-Riyami, Lamyaa and Gharakhanian, Raffi and Harnett, Margaret M. and Harnett, William and Rifkin, Ian R. (2015) The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. International Journal for Parasitology, 45 (4). pp. 203-207. ISSN 0020-7519

Rzepecka, Justyna and Coates, Michelle and Saggar, Moninder and Al-Riyami, Lamyaa and Coltherd, Jennifer and Tay, Hwee Kee and Huggan, Judith and Janicova, Lucia and Khalaf, Abedawn and Siebeke, Ivonne and Suckling, Colin and Harnett, Margaret and Harnett, William (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44 (9). pp. 669-674. ISSN 0020-7519

Pineda, M.A. and Al-Riyami, L. and Harnett, W. and Harnett, M.M. (2014) Lessons from helminth infections : ES-62 highlights new interventional approaches in rheumatoid arthritis. Clinical and Experimental Immunology, 177 (1). pp. 13-23. ISSN 0009-9104

Pineda, Miguel A and Rodgers, David T and Al-Riyami, Lamyaa and Harnett, William and Harnett, Margaret (2014) ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints. Arthritis and Rheumatism, 66 (6). 1492–1503. ISSN 0004-3591

Rodgers, David T. and Pineda, Miguel A. and McGrath, Mairi A. and Al-Riyami, Lamyaa and Harnett, William and Harnett, Margaret M. (2014) Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of IL-10-producing B cells and reduced plasma cell infiltration of the joints. Immunology, 141 (3). 457–466. ISSN 0019-2805

Rzepecka, Justyna and Siebeke, Ivonne and Coltherd, Jennifer and Kean, Dorothy and Steiger, Christina and Al-Riyami, Lamyaa and McSharry, Charles and Harnett, Margaret and Harnett, William (2013) The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype. International Journal for Parasitology, 43 (3-4). 211–223. ISSN 0020-7519

Al-Riyami, Lamyaa and Pineda, Miguel and Rzepecka, Justyna and Huggan, Judith and Khalaf, Abedawn and Suckling, Colin and Rodgers, David and Harnett, Margaret and Harnett, William and Scott, Fraser (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis : Helminth-based synthetic compound protects against CIA. Journal of Medicinal Chemistry, 56. pp. 9982-10002. ISSN 0022-2623

Harnett, W. and Al-Riyami, L. and Rzepecka, J. and Harnett, M. M.; Kennedy, M. W. and Harnett, W., eds. (2013) Modulation of autoimmune and allergic responses by defined nematode molecules. In: Parasitic Nematodes. CABI, pp. 144-155. ISBN 9781845937591

Pineda, Miguel and McGrath, Mairi and Smith, Pauline and Al-Riyami, Lamyaa and Rzepecka, Justyna and Gracie, Alastair and Harnett, William and Harnett, Margaret (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64 (10). 3168–3178. ISSN 0004-3591

Al-Riyami, Lamyaa and Harnett, William (2012) Immunomodulatory properties of ES-62, a phosphorylcholine-containing glycoprotein secreted by Acanthocheilonema viteae. Endocrine, Metabolic and Immune Disorders-Drug Targets, 12 (1). pp. 45-52. ISSN 2212-3873

Al-Riyami, Lamyaa and Rzepecka, Justyna and Khalaf, Abedawn and Suckling, Colin and Harnett, M. and Harnett, William (2010) Small molecule analogues of an immunomodulatory helminth product provide a novel approach to dissecting macrophage signal transduction pathways : Poster abstract. Immunology, 131 (Supple). p. 164. ISSN 0019-2805

Al-Riyami, L. and Wilson, E.H. and Watson, C.A. and Harnett, W. (2009) T-helper type 1 responses to the bcg vaccine component ppd in mice are unaffected by the filarial nematode immunomodulatory molecule es-62. Journal of Parasitology, 95 (5). pp. 1201-1204.

Al-Riyami, Lamyaa and Egan, C.A. and Bradley, J.E. and Lustigman, S. and Harnett, W. (2008) Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens. Parasite Immunology, 30 (5). pp. 304-308. ISSN 0141-9838

Harnett, M.M. and Kean, Dorothy E. and Boitelle, A. and McGuiness, S. and Thalhamer, T. and Steiger, C.N. and Egan, Caitlin and Al-Riyami, Lamyaa and Alcocer, Marcos J.C. and Houston, Katrina M. and Gracie, J.A. and McInnes, I.B. and Harnett, W. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67 (4). pp. 518-523. ISSN 0003-4967

Goodridge, H.S. and Marshall, F.A. and Else, K.J. and Houston, K.M. and Egan, C. and Al-Riyami, L.R. and Liew, F.Y. and Harnett, W. and Harnett, M.M. (2005) Immunomodulation via Novel Use of TLR4 by the Filarial Nematode Phosphorylcholine-Containing Secreted Product, ES-621. Journal of Immunology, 174 (1). pp. 284-293. ISSN 0022-1767

Goodridge, Helen S. and Marshall, Fraser A. and Else, Kathryn J. and Houston, Katrina M. and Egan, Caitlin and Al-Riyami, Lamyaa and Liew, Foo-Yew and Harnett, William and Harnett, Margaret M. (2005) Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine (PC)-containing secreted product, ES-62. Journal of Immunology, 174. pp. 284-293. ISSN 0022-1767