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Modulation of autoimmune and allergic responses by defined nematode molecules

Harnett, W. and Al-Riyami, L. and Rzepecka, J. and Harnett, M. M. (2013) Modulation of autoimmune and allergic responses by defined nematode molecules. In: Parasitic Nematodes. CABI, pp. 144-155. ISBN 9781845937591

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This chapter explores the immunomodulatory effects of nematode infections which protect the host against autoimmune and allergic diseases. Included are discussions on specific nematode molecules (i.e., Ascaris suum PAS-1, cystatins, Dirofilaria immitis-derived antigen (DiAg), galectin-9 homologue of Toxascaris leonina (Tl-GAL), ES-62) that exert immunomodulatory properties in animal studies and their probable mechanisms of action.