Acceptability of Acceptance and Commitment Therapy for medication-decision-making and quality of life in women with breast cancer : a qualitative process evaluation

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Green, Sophie M.C. and Hall, Louise H. and Ellison, Rachel and Clark, Jane and Wilkes, Hollie and Hartley, Suzanne and Naik, Jay and Buckley, Sarah and Hirst, Charlotte and Hartup, Sue and Neal, Richard D. and Velikova, Galina and Farrin, Amanda and Collinson, Michelle and Graham, Christopher D. and Smith, Samuel G. (2025) Acceptability of Acceptance and Commitment Therapy for medication-decision-making and quality of life in women with breast cancer : a qualitative process evaluation. British Journal of Health Psychology. ISSN 1359-107X (In Press)

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Abstract

Objectives: Adjuvant endocrine therapy (AET) reduces breast cancer recurrence, but side-effects and distress impact adherence. We co-designed an Acceptance and Commitment Therapy (ACT) intervention to support medication decision-making and quality of life in women prescribed AET (ACTION). In a qualitative process evaluation nested in the pilot trial, we aimed to elicit participant experiences of receipt and therapists experience of delivery of ACTION to enhance our understanding of acceptability. Design: Remote semi-structured interviews were conducted with women with breast cancer who received ACTION (n=20), and trial therapists (n=3). Methods: Interviews were guided by the Theoretical Framework of Acceptability (TFA). Rapid Assessment Procedure (RAP) sheets were completed after each interview to map responses onto TFA constructs, and sections of interviews were selectively transcribed. Individual RAP sheets were collated to identify key findings. Results: ACTION was generally liked, in particular the group format (affective attitude). Participants and therapists felt ACTION was low effort, but therapists acknowledged burden associated with trial procedures (burden). Participants generally felt able to engage with ACTION, and therapists felt they were able to deliver it (self-efficacy). Perceived effectiveness of ACTION on wellbeing was good, but was mixed for impact on treatment adherence (perceived effectiveness). Participants and therapists understood the aims of ACTION (coherence), and ACTION generally aligned with therapist’s values (ethicality). Therapists questioned who would be most appropriate to deliver ACTION (opportunity costs). Conclusion: ACTION was acceptable to women with breast cancer and trial therapists. Rapid qualitative analysis can facilitate efficient process evaluations in time- and resource-limited contexts. Keywords: acceptance and commitment therapy; acceptability; breast cancer; adjuvant endocrine therapy, process evaluation, rapid assessment procedure

ORCID iDs

Green, Sophie M.C., Hall, Louise H., Ellison, Rachel, Clark, Jane, Wilkes, Hollie, Hartley, Suzanne, Naik, Jay, Buckley, Sarah, Hirst, Charlotte, Hartup, Sue, Neal, Richard D., Velikova, Galina, Farrin, Amanda, Collinson, Michelle, Graham, Christopher D. ORCID logoORCID: https://orcid.org/0000-0001-8456-9154 and Smith, Samuel G.;
CORE (COnnecting REpositories)