A randomised controlled trial of acceptance and commitment therapy for improving quality of life in people with muscle diseases
Rose, Michael and Graham, Christopher D. and O'Connell, Nicola and Vari, Chiara and Edwards, Victoria and Taylor, Emma and McCracken, Lance M. and Radunovic, Aleksander and Rakowicz, Wojtek and Norton, Sam and Chalder, Trudie (2022) A randomised controlled trial of acceptance and commitment therapy for improving quality of life in people with muscle diseases. Psychological Medicine. pp. 1-14. ISSN 0033-2917 (https://doi.org/10.1017/S0033291722000083)
Preview |
Text.
Filename: Rose_etal_PM_2022_A_randomised_controlled_trial_of_acceptance_and_commitment_therapy.pdf
Final Published Version License: Download (654kB)| Preview |
Abstract
Background Chronic muscle diseases (MD) are progressive and cause wasting and weakness in muscles and are associated with reduced quality of life (QoL). The ACTMuS trial examined whether Acceptance and Commitment Therapy (ACT) as an adjunct to usual care improved QoL for such patients as compared to usual care alone. Methods This two-arm, randomised, multicentre, parallel design recruited 155 patients with MD (Hospital and Depression Scale ≥ 8 for depression or ≥ 8 for anxiety and Montreal Cognitive Assessment ≥ 21/30). Participants were randomised, using random block sizes, to one of two groups: standard medical care (SMC) (n = 78) or to ACT in addition to SMC (n = 77), and were followed up to 9 weeks. The primary outcome was QoL, assessed by the Individualised Neuromuscular Quality of Life Questionnaire (INQoL), the average of five subscales, at 9-weeks. Trial registration was NCT02810028. Results 138 people (89.0%) were followed up at 9-weeks. At all three time points, the adjusted group difference favoured the intervention group and was significant with moderate to large effect sizes. Secondary outcomes (mood, functional impairment, aspects of psychological flexibility) also showed significant differences between groups at week 9. Conclusions ACT in addition to usual care was effective in improving QoL and other psychological and social outcomes in patients with MD. A 6 month follow up will determine the extent to which gains are maintained.
ORCID iDs
Rose, Michael, Graham, Christopher D. ORCID: https://orcid.org/0000-0001-8456-9154, O'Connell, Nicola, Vari, Chiara, Edwards, Victoria, Taylor, Emma, McCracken, Lance M., Radunovic, Aleksander, Rakowicz, Wojtek, Norton, Sam and Chalder, Trudie;-
-
Item type: Article ID code: 84690 Dates: DateEvent23 February 2022Published23 February 2022Published Online6 January 2022AcceptedSubjects: Philosophy. Psychology. Religion > Psychology Department: Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and Health > Psychology Depositing user: Pure Administrator Date deposited: 13 Mar 2023 16:31 Last modified: 01 Dec 2024 22:28 URI: https://strathprints.strath.ac.uk/id/eprint/84690