Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity

Khalaf, A.I. and Waigh, R.D. and Drummond, A.J. and Pringle, B. and McGroarty, I. and Skellern, G.G. and Suckling, C.J. (2004) Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity. Journal of Medicinal Chemistry, 47 (8). pp. 2133-2156. ISSN 0022-2623 (http://dx.doi.org/10.1021/jm031089x)

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Abstract

Forty-eight heterocyclic amino acid trimers, analogues of distamycin, with a number of features that enhance lipophilicity are described. They contain alkyl or cycloalkyl groups larger than methyl; some are N-terminated by acetamide or methoxybenzamide and are C-terminated by dimethylaminopropyl or aliphatic heterocylic aminopropyl substituents. The ability of these compounds to bind principally to AT tracts of DNA has been evaluated using capillary zone electrophoresis. Significant antimicrobial activity against key organisms such as MRSA and Candida albicans is shown by several compounds, especially those containing a thiazole. Moreover, these compounds have low toxicity with respect to several mammalian cell lines.

ORCID iDs

Khalaf, A.I. ORCID logoORCID: https://orcid.org/0000-0001-9162-7527, Waigh, R.D., Drummond, A.J., Pringle, B., McGroarty, I., Skellern, G.G. and Suckling, C.J.;
CORE (COnnecting REpositories)