Improving the prediction of multi-component tablet properties from pure component parameters

Tools

Jolliffe, Hikaru G. and Papathanasiou, Foteini and Prasad, Elke and Halbert, Gavin and Robertson, John and Brown, Cameron J. and Florence, Alastair J.; (2019) Improving the prediction of multi-component tablet properties from pure component parameters. In: 29th European Symposium on Computer Aided Chemical Engineering. Computer Aided Chemical Engineering, 46 . Elsevier, NLD, pp. 883-888. ISBN 9780128186350 (https://doi.org/10.1016/B978-0-12-818634-3.50148-X)

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Abstract

Direct compaction tabletting, a widely used secondary downstream processing operation, has recently received significant research attention. Experimental data can be used to fit model parameters for the prediction of single-component tablet thickness and hardness with good agreement, and this has been done for two components (Avicel® PH-101 and Pharmatose® 50M). These pure component parameters have then been used to predict multicomponent tablet properties, with the use of novel modified parameter averaging calculations improving predictions. Furthermore, a relation has been developed to estimate the required gap between tablet press punch faces for multicomponent tablets based on the gaps required for pure components; a quick and efficient way to estimate the necessary equipment settings to generate the desired compaction forces is a useful tool.

ORCID iDs

Jolliffe, Hikaru G., Papathanasiou, Foteini, Prasad, Elke ORCID logoORCID: https://orcid.org/0000-0002-5412-9374, Halbert, Gavin, Robertson, John ORCID logoORCID: https://orcid.org/0000-0002-2191-1319, Brown, Cameron J. ORCID logoORCID: https://orcid.org/0000-0001-7091-1721 and Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;
CORE (COnnecting REpositories)