Amidation of unactivated ester derivatives mediated by trifluoroethanol

McPherson, Christopher G. and Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Watson, Allan J. B. (2017) Amidation of unactivated ester derivatives mediated by trifluoroethanol. Organic and Biomolecular Chemistry. ISSN 1477-0520 (https://doi.org/10.1039/C7OB00593H)

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Abstract

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

ORCID iDs

McPherson, Christopher G. ORCID: https://orcid.org/0000-0002-3082-0515

Jamieson, Craig ORCID: https://orcid.org/0000-0002-6567-8272

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• Item metadata

  Item type:	Article
  ID code:	60404
  Dates:	Date Event 4 April 2017 Published 4 April 2017 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Strategic Research Themes > Health and Wellbeing
  Depositing user:	Pure Administrator
  Date deposited:	05 Apr 2017 10:59
  Last modified:	11 Nov 2024 11:40
  URI:	https://strathprints.strath.ac.uk/id/eprint/60404