The role of sphingosine 1-phosphate in inflammation and cancer

Pyne, Nigel J and Ohotski, Jan and Bittman, Robert and Pyne, Susan (2014) The role of sphingosine 1-phosphate in inflammation and cancer. Advances in Biological Regulation, 54. pp. 121-129. ISSN 2212-4934 (https://doi.org/10.1016/j.jbior.2013.08.005)

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Abstract

The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available molecular and chemical inhibitors. Thus, there is a compelling case for therapeutic targeting of sphingosine kinase. In addition, there are several examples of functional interaction between sphingosine 1-phosphate receptors and sphingosine kinase 1 that can drive malicious amplification loops that promote cancer cell growth. These novel aspects of sphingosine 1-phosphate pathobiology are reviewed herein.

  • Item type:Article
    ID code:49243
    Dates:
    Date
    Event
    January 2014
    Published
    11 September 2013
    Published Online
    Notes:Notice: This is the author's version of a work that was accepted for publication in Advances in Biological Regulation. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in: Advances in Biological Regulation, The role of sphingosine 1-phosphate in inflammation and cancer, Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S. Jan 2014. 54, p. 121-129. DOI: 10.1016/j.jbior.2013.08.005.
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:15 Sep 2014 13:41
    Last modified:14 Apr 2024 00:28
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/49243
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