Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

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Burns, Alan R. and Kerr, Jennifer H. and Kerr, William J. and Passmore, Joanna and Paterson, Laura C. and Watson, Allan J. B. (2010) Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs. Organic and Biomolecular Chemistry, 8 (12). pp. 2777-2783. ISSN 1477-0520 (https://doi.org/10.1039/c001772h)

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

ORCID iDs

Burns, Alan R., Kerr, Jennifer H., Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X, Passmore, Joanna, Paterson, Laura C. and Watson, Allan J. B.;
  • Item type:Article
    ID code:27525
    Dates:
    Date
    Event
    2010
    Published
    28 April 2010
    Published Online
    Notes:M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2010:681760(Journal)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Ms Carol Khalaf
    Date deposited:01 Oct 2010 13:31
    Last modified:11 Nov 2024 09:33
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/27525
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