Improving the prediction of multi-component tablet properties from pure component parameters

Jolliffe, Hikaru G. and Papathanasiou, Foteini and Prasad, Elke and Halbert, Gavin and Robertson, John and Brown, Cameron J. and Florence, Alastair J.; (2019) Improving the prediction of multi-component tablet properties from pure component parameters. In: 29th European Symposium on Computer Aided Chemical Engineering. Computer Aided Chemical Engineering, 46 . Elsevier, NLD, pp. 883-888. ISBN 9780128186350 (https://doi.org/10.1016/B978-0-12-818634-3.50148-X)

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Abstract

Direct compaction tabletting, a widely used secondary downstream processing operation, has recently received significant research attention. Experimental data can be used to fit model parameters for the prediction of single-component tablet thickness and hardness with good agreement, and this has been done for two components (Avicel® PH-101 and Pharmatose® 50M). These pure component parameters have then been used to predict multicomponent tablet properties, with the use of novel modified parameter averaging calculations improving predictions. Furthermore, a relation has been developed to estimate the required gap between tablet press punch faces for multicomponent tablets based on the gaps required for pure components; a quick and efficient way to estimate the necessary equipment settings to generate the desired compaction forces is a useful tool.

ORCID iDs

Jolliffe, Hikaru G., Papathanasiou, Foteini, Prasad, Elke ORCID logoORCID: https://orcid.org/0000-0002-5412-9374, Halbert, Gavin, Robertson, John ORCID logoORCID: https://orcid.org/0000-0002-2191-1319, Brown, Cameron J. ORCID logoORCID: https://orcid.org/0000-0001-7091-1721 and Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;
CORE (COnnecting REpositories)