Amidation of unactivated ester derivatives mediated by trifluoroethanol

McPherson, Christopher G. and Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Watson, Allan J. B. (2017) Amidation of unactivated ester derivatives mediated by trifluoroethanol. Organic and Biomolecular Chemistry. ISSN 1477-0520 (https://doi.org/10.1039/C7OB00593H)

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Abstract

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

ORCID iDs

McPherson, Christopher G. ORCID logoORCID: https://orcid.org/0000-0002-3082-0515, Caldwell, Nicola, Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272, Simpson, Iain and Watson, Allan J. B.;
  • Item type:Article
    ID code:60404
    Dates:
    Date
    Event
    4 April 2017
    Published
    4 April 2017
    Accepted
    Keywords:amidation, ester derivatives, trifluoroethanol, chiral integrity, catalytic amidation protocol, acyclic secondary amines, Chemistry, Organic Chemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Strategic Research Themes > Health and Wellbeing
    Depositing user: Pure Administrator
    Date deposited:05 Apr 2017 10:59
    Last modified:24 Sep 2022 02:31
    URI:https://strathprints.strath.ac.uk/id/eprint/60404
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