Amidation of unactivated ester derivatives mediated by trifluoroethanol
McPherson, Christopher G. and Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Watson, Allan J. B. (2017) Amidation of unactivated ester derivatives mediated by trifluoroethanol. Organic and Biomolecular Chemistry. ISSN 1477-0520
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Official URL: https://doi.org/10.1039/C7OB00593H
Abstract
A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.
ORCID iDs
McPherson, Christopher G.
ORCID: https://orcid.org/0000-0002-3082-0515, Caldwell, Nicola, Jamieson, Craig ORCID: https://orcid.org/0000-0002-6567-8272, Simpson, Iain and Watson, Allan J. B.;
Item type: Article ID code: 60404 Dates: DateEvent4 April 2017Published4 April 2017AcceptedKeywords: amidation, ester derivatives, trifluoroethanol, chiral integrity, catalytic amidation protocol, acyclic secondary amines, Chemistry, Organic Chemistry Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Strategic Research Themes > Health and WellbeingDepositing user: Pure Administrator Date deposited: 05 Apr 2017 10:59 Last modified: 23 Feb 2021 02:27 URI: https://strathprints.strath.ac.uk/id/eprint/60404
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)