Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Wilson, Kirsty and Kennedy, Alan and Murray, Jane and Greatex, Ben and Jamieson, Craig and Watson, Allan (2016) Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation. Beilstein Journal of Organic Chemistry, 12. pp. 2005-2011. ISSN 1860-5397 (https://doi.org/10.3762/bjoc.12.187)

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Abstract

Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (CyreneTM) in Sonogashira crosscoupling and Cacchi-type annulations.

ORCID iDs

Wilson, Kirsty ORCID: https://orcid.org/0000-0002-4382-6246

Kennedy, Alan ORCID: https://orcid.org/0000-0003-3652-6015

Jamieson, Craig ORCID: https://orcid.org/0000-0002-6567-8272

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• Item metadata

  Item type:	Article
  ID code:	57887
  Dates:	Date Event 8 September 2016 Published 22 August 2016 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	21 Sep 2016 12:57
  Last modified:	03 Dec 2024 01:15
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/57887