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2024

Jackson, Mark R. and Richards, Amanda R. and Ayoola Oladipupo, Abdul-Basit and Chahal, Sandeep K. and Carager, Seamus and Chalmers, Anthony J. and Gomez-Roman, Natividad (2024) ClonoScreen3D – a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma. International Journal of Radiation Oncology - Biology - Physics, 120 (1). pp. 162-177. ISSN 1879-355X

Vens, C. and van Luijk, P. and Vogelius, R.I. and El Naqa, I. and Humbert-Vidan, L. and von Neubeck, C. and Gomez-Roman, N. and Bahn, E. and Brualla, L. and Böhlen, T.T. and Ecker, S. and Koch, R. and Handeland, A. and Pereira, S. and Possenti, L. and Rancati, T. and Todor, D. and Vanderstraeten, B. and Van Heerden, M. and Ullrich, W. and Jackson, M. and Alber, M. and Marignol, L. (2024) A joint physics and radiobiology DREAM team vision - towards better response prediction models to advance radiotherapy. Radiotherapy and Oncology, 196. 110277. ISSN 1879-0887

2023

Jackson, Mark R and R Richards, Amanda and Ayoola Oladipupo, Abdul-Basit and Chahal, Sandeep K and Carager, Seamus and Chalmers, Anthony J and Gomez-Roman, Natividad (2023) ClonoScreen3D : a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma. Preprint / Working Paper. bioRxiv, Cold Spring Harbor.

2022

Rominiyi, Ola and Myers, Katie and Gomez-Roman, Natividad and Jellinek, David A and Chalmers, Anthony J and Carroll, Thomas A and Chen, Beining and Al-Tamimi, Yahia and Collis, Spencer (2022) Combined inhibition of the Fanconi anaemia (FA) pathway and ATR promotes R-loop generation and profound radiosensitisation in glioblastoma. Brain Tumour Research and Treatment, S253. ISSN 2288-2405

2021

Rominiyi, Ola and Vanderlinden, A and Myers, K. and Gomez-Roman, Natividad and Dar, D. and Bagga, V. and Jellinek, D. A. and Chalmers, Anthony and Carroll, T. A. and Al-Tamimi, Y. and Collis, S. J. (2021) O2 : Towards a living biobank of surgically-relevant 3-dimensional glioblastoma stem cell models to evaluate novel therapeutics and interrogate intratumoural heterogeneity. British Journal of Surgery, 108 (Suppl ). znab117.002. ISSN 1365-2168

Guttierez-Quintana, Rodrigo and Walker, David J. and Jackson, Mark R. and Gomez-Roman, Natividad and Chahal, Sandeep and Durant, Stephen T. and Chalmers, Anthony J. (2021) Abstract PO-017 : radiotherapy in combination with the brain penetrant ATM inhibitor AZD1390 does not exacerbate radiation toxicity of neural stem cells in vitro or in vivo. Clinical Cancer Research, 27 (8_Supp). PO-017. ISSN 1078-0432

2020

Koessinger, Anna L. and Koessinger, Dominik and Stevenson, Katrina and Cloix, Catherine and Mitchell, Louise and Nixon, Colin and Gomez-Roman, Natividad and Chalmers, Anthony J. and Norman, Jim C. and Tait, Stephen W. G. (2020) Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10 (1). 15361. ISSN 2045-2322

Gomez-Roman, Natividad and Chong, Ming Y. and Chahal, Sandeep K. and Caragher, Seamus P. and Jackson, Mark R. and Stevenson, Katrina H. and Dongre, Sidhartha A. and Chalmers, Anthony J. (2020) Radiation responses of 2D and 3D glioblastoma cells : a novel, 3D-specific radioprotective role of VEGF/Akt signaling through functional activation of NHEJ. Molecular Cancer Therapeutics, 19 (2). pp. 575-589. ISSN 1535-7163

2019

Gomez-Roman, Natividad and Jackson, Mark and Chalmers, Anthony (2019) Cholesterol protects glioblastoma cells against premature mitosis. Neuro-Oncology, 21 (Suppl ). iv7. ISSN 1522-8517

Jackson, Mark and Gomez-Roman, Natividad and Chalmers, Anthony (2019) Inhibitors of poly(ADP-ribose) glycohydrolase (PARG) exhibit single agent therapeutic activity and sensitize glioblastoma cells to ionizing radiation. Clinical Cancer Research, 21 (supp 4). iv12. ISSN 1078-0432

Caragher, Seamus and Chalmers, Anthony J. and Gomez-Roman, Natividad (2019) Glioblastoma's next top model : novel culture systems for brain cancer radiotherapy research. Cancers, 11 (1). 44. ISSN 2072-6694

2018

Carruthers, Ross D. and Ahmed, Shafiq U. and Ramachandran, Shaliny and Strathdee, Karen and Kurian, Kathreena M. and Hedley, Ann and Gomez-Roman, Natividad and Kalna, Gabriela and Neilson, Mathew and Gilmour, Lesley and Stevenson, Katrina H. and Hammond, Ester M. and Chalmers, Anthony J. (2018) Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research, 78 (17). pp. 5060-5071. ISSN 0008-5472

Gomez-Roman, N. and Chalmers, A. J. (2018) OS1.4 Induction of mitotic cell death : a novel therapeutic strategy for glioblastoma. Neuro-Oncology, 20 (Suppl ). iii217-iii218. ISSN 1522-8517

Rominiyi, O. and Gomez-Roman, N. and Lad, N. and Al-Tamimi, Y. and Jellinek, D. A. and Chalmers, A. J. and Carroll, T. A. and Chen, B. and Collis, S. J. (2018) P04.74 Preclinical evaluation of combinations targeting the DNA damage response in 2D and 3D models of glioblastoma stem cells. Neuro-Oncology, 20 (Suppl_). iii297. ISSN 1522-8517

Gomez-Roman, Natividad and Stevenson, Katrina and Chong, Ming Yao and Gilmour, Lesley and Chalmers, Anthony (2018) Regulation of DNA double strand break repair by EGF and VEGF signalling reveals Akt to be a critical therapeutic target in glioblastoma. Neuro-Oncology, 20 (Issue ). i7. ISSN 1522-8517

2017

Gomez-Roman, Natividad and Stevenson, Katrina and Gilmour, Lesley and Hamilton, Graham and Chalmers, Anthony J (2017) A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses. Neuro-Oncology, 19 (2). pp. 229-241. ISSN 1522-8517

2016

Gomez-Roman, N. and Chalmers, A. (2016) The impact of a novel 3D cell culture model of glioblastoma on radiation and drug-radiation responses. Radiotherapy and Oncology, 119 (S1). S280-S281.

Gomez-Roman, Natividad and Sahasrabudhe, Neha Mohan and McGregor, Fiona and Chalmers, Anthony J and Cassidy, Jim and Plumb, Jane (2016) Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget, 7 (16). pp. 22650-22664. ISSN 1949-2553

2015

Gomez-Roman, Natividad and McGregor, Fiona and Wheate, Nial J. and Plumb, Jane A. (2015) Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model. Journal of Ovarian Research, 8 (1). pp. 1-10. 62. ISSN 1757-2215

Carruthers, Ross and Ahmed, Shafiq U. and Strathdee, Karen and Gomez-Roman, Natividad and Amoah-Buahin, Evelyn and Watts, Colin and Chalmers, Anthony J. (2015) Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase. Molecular Oncology, 9 (1). pp. 192-203. ISSN 1878-0261

2014

Mannino, Mariella and Gomez-Roman, Natividad and Hochegger, Helfrid and Chalmers, Anthony J. (2014) Differential sensitivity of glioma stem cells to aurora kinase A inhibitors : implications for stem cell mitosis and centrosome dynamics. Stem Cell Research, 13 (1). pp. 135-143. ISSN 1873-5061

2009

Bilsland, Alan E. and Hoare, Stacey and Stevenson, Katrina and Plumb, Jane and Gomez-Roman, Natividad and Cairney, Claire and Burns, Sharon and Lafferty-Whyte, Kyle and Roffey, Jon and Hammonds, Tim and Keith, W. Nicol (2009) Dynamic telomerase gene suppression via network effects of GSK3 inhibition. PLoS ONE, 4 (7). e6459. ISSN 1932-6203