Synthesis of a benzotriazole phosphoramidite for attachment of oligonucleotides to metal surfaces

Brown, R. and Smith, W.E. and Graham, D. (2001) Synthesis of a benzotriazole phosphoramidite for attachment of oligonucleotides to metal surfaces. Tetrahedron Letters, 42 (11). pp. 2197-2200. ISSN 0040-4039 (http://dx.doi.org/10.1016/S0040-4039(01)00108-3)

Abstract

A method for the addition of a benzotriazole moiety to the 5'-terminus of an oligonucleotide via phosphoramidite chemistry has been developed. Use of a monomethoxytrityl protecting group on the benzotriazole allowed fast on-column detritylation purification by reverse-phase HPLC. Surface enhanced Raman scattering (SERS) of the modified oligonucleotides was obtained from silver colloid.

• Share and Export
  

  RDF+XMLBibTeXRIOXX2 XMLRDF+N-TriplesJSONDublin CoreAtomSimple MetadataReferMETSHTML CitationASCII CitationOpenURL ContextObjectEndNoteOpenURL ContextObject in SpanMODSMPEG-21 DIDLEP3 XMLData Cite XMLRIS (EndNote Online, Zotero, Ref manager, etc)RDF+N3Multiline CSV
• Item metadata

  Item type:	Article
  ID code:	967
  Dates:	Date Event 11 March 2001 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Unknown Department
  Depositing user:	Mr Derek Boyle
  Date deposited:	05 May 2006
  Last modified:	08 Apr 2024 15:20
  Related URLs:	http://www.sciencedirect.com/science?_ob...
  URI:	https://strathprints.strath.ac.uk/id/eprint/967