Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups

Mackellar, C. and Graham, D. and Will, D.W. and Burgess, S. and Brown, T. (1992) Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups. Nucleic Acids Research, 20 (13). pp. 3411-3417. ISSN 0305-1048 (http://dx.doi.org/10.1093/nar/20.13.3411)

Abstract

A number of phosphoramidite monomers have been prepared and used in the synthesis of antisense phosphorothioate oligonucleotides bearing 5'-polyalkyl and cholesterol moieties. Similar groups have also been attached to the 3'-end of oligonucleotides by means of functionalised CPG. Melting temperatures of duplexes formed between phosphorothioate oligonucleotides with lipophilic end-groups and complementary DNA strands were found to be identical to those formed by the equivalent unmodified phosphorothioates.

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• Item metadata

  Item type:	Article
  ID code:	947
  Dates:	Date Event 11 July 1992 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Faculty of Humanities and Social Sciences (HaSS) > Humanities > History
  Depositing user:	Mr Derek Boyle
  Date deposited:	04 May 2006
  Last modified:	08 Apr 2024 15:15
  URI:	https://strathprints.strath.ac.uk/id/eprint/947