3D printing MicroFactory for amorphous solid dispersion formulations

Prasad, Elke and Hueckman, Jill and Bordos, Ecaterina and Robertson, John and Halbert, Gavin W. (2024) 3D printing MicroFactory for amorphous solid dispersion formulations. In: CMAC Summer School 2024, 2023-07-10 - 2024-07-14.

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Abstract

This study utilised the HUB Additive-ManufacturingMicroFactory as an enabler for streamlined manufacture of Amorphous Solid Dispersion (ASD) formulation of the model compound Ritonavir with an immediate release polymer Soluplus® (BASF). The Digital Design and Manufacture of Amorphous Pharmaceuticals (DDMAP) research program identified Soluplus® as a superior polymer to form stable ASD formulation with Ritonavir. The drug release from 3D printed (3DP) Ritonavir ASD formulations with Soluplus® were compared to a commercial product (Norvir, 100mg, Abbvie Ltd).

ORCID iDs

Prasad, Elke ORCID logoORCID: https://orcid.org/0000-0002-5412-9374, Hueckman, Jill, Bordos, Ecaterina, Robertson, John ORCID logoORCID: https://orcid.org/0000-0002-2191-1319 and Halbert, Gavin W.;
CORE (COnnecting REpositories)