Experiences of melt fi ll production of Fenretinide/Lym-X-Sorb™ hard gelatin capsules for Phase I clinical trial

Elliott, M.A. and Prasad, E. and Ford, S.J. and Halbert, G.W. (2010) Experiences of melt fi ll production of Fenretinide/Lym-X-Sorb™ hard gelatin capsules for Phase I clinical trial. In: UK-PharmSci 2010 – The Science of Medicines, 2010-09-01 - 2010-09-03.

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Abstract

Fenretinide is a pro-apoptotic, cytotoxic, synthetic Vitamin A analogue with application in the treatment of Ewing’s sarcoma. For pediatric study, a ‘cookie dough’ formulation had been developed, improving upon an existing corn oil formulation. We report on a simplified capsular formulation of Fenretinide with the novel solubility and bioavailability enhancing lipid matrix, Lym-X-Sorb™.

ORCID iDs

Elliott, M.A. ORCID logoORCID: https://orcid.org/0000-0002-9964-5671, Prasad, E. ORCID logoORCID: https://orcid.org/0000-0002-5412-9374, Ford, S.J. and Halbert, G.W.;
CORE (COnnecting REpositories)