The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors

Gopal, P. and Tate, R. and Pow, E. and Hill, D. and Connolly, J.G. (2007) The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors. British Journal of Pharmacology, 150 (7). pp. 920-931. ISSN 1476-5381 (http://dx.doi.org/10.1038/sj.bjp.0707156)

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Abstract

Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites.

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