Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion : HPMC-Affinisol paracetamol system

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Islam, M.T. and Robertson, J. and Florence, A.J. (2016) Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion : HPMC-Affinisol paracetamol system. In: 2016 AAPS Annual meeting and exposition, 2016-11-13 - 2016-11-17, Colorado Convention Center. (In Press)

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Abstract

The aim of this work is to: (1) Determine the viable processing window of HPMC-Affinisol polymer to use in hot melt extrusion. (2) Use this polymer for oral formulations with Paracetamol over a wide range of physical grades and determine the effect of API particle size on the nature of the resulting formulated mixtures. (3) Assess if HME can be used to produce a consistent output with wide ranges in physical input API properties.

ORCID iDs

Islam, M.T. ORCID logoORCID: https://orcid.org/0000-0002-3530-0519, Robertson, J. ORCID logoORCID: https://orcid.org/0000-0002-2191-1319 and Florence, A.J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;
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