One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol

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Kyne, Sara H and Percy, Jonathan M and Pullin, Robert D C and Redmond, Joanna M and Wilson, Peter G (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 1477-0520 (https://doi.org/10.1039/C1OB06372C)

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Abstract

Difluoroalkenylzinc reagents prepared from 1-(2’-methoxy-ethoxymethoxy)-2,2,2-trifluoroethane and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane at ice bath temperatures, underwent Negishi coupling with a range of aryl halides in a convenient one pot procedure. While significant differences between the enol acetal and carbamate reagents were revealed, the Negishi protocol compared very favourably with alternative coupling procedures in terms of overall yields from trifluoroethanol.

ORCID iDs

Kyne, Sara H, Percy, Jonathan M ORCID logoORCID: https://orcid.org/0000-0001-8636-2704, Pullin, Robert D C, Redmond, Joanna M and Wilson, Peter G;
  • Item type:Article
    ID code:35446
    Dates:
    Date
    Event
    2011
    Published
    15 September 2011
    Published Online
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:01 Nov 2011 16:24
    Last modified:21 Dec 2024 01:11
    URI:https://strathprints.strath.ac.uk/id/eprint/35446
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