Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

Dick, Lindsay and Dooley, Neil and Elliott, Moira A and Ford, Steven J and Gordon, Malcolm R and Halbert, Gavin W and Kerr, William J (2011) Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways. Journal of Pharmaceutical and Biomedical Analysis, 56 (3). pp. 633-636. (https://doi.org/10.1016/j.jpba.2011.06.025)

Abstract

Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

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• Item metadata

  Item type:	Article
  ID code:	34327
  Dates:	Date Event 1 November 2011 Published 1 July 2011 Published Online
  Notes:	Copyright © 2011 Elsevier B.V. All rights reserved.
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
  Depositing user:	Pure Administrator
  Date deposited:	27 Jan 2012 13:19
  Last modified:	08 Apr 2024 19:30
  Related URLs:	Scopus publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/34327