Control of enhanced raman scattering using a DNA-based assembly process of dye-coded nanoparticles

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Graham, D. and Thompson, D.G. and Smith, W.E. and Faulds, K. (2008) Control of enhanced raman scattering using a DNA-based assembly process of dye-coded nanoparticles. Nature Nanotechnology, 3 (9). pp. 548-551. ISSN 1748-3387 (https://doi.org/10.1038/nnano.2008.189)

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Abstract

Enhanced Raman scattering from metal surfaces has been investigated for over 30 years1. Silver surfaces are known to produce a large effect, and this can be maximized by producing a roughened surface, which can be achieved by the aggregation of silver nanoparticles2, 3, 4. However, an approach to control this aggregation, in particular through the interaction of biological molecules such as DNA, has not been reported. Here we show the selective turning on of the surface enhanced resonance Raman scattering5 effect on dye-coded, DNA-functionalized, silver nanoparticles through a target-dependent, sequence-specific DNA hybridization assembly that exploits the electromagnetic enhancement mechanism for the scattering. Dye-coded nanoparticles that do not undergo hybridization experience no enhancement and hence do not give surface enhanced resonance Raman scattering. This is due to the massive difference in enhancement from nanoparticle assemblies compared with individual nanoparticles. The electromagnetic enhancement is the dominant effect and, coupled with an understanding of the surface chemistry, allows surface enhanced resonance Raman scattering nanosensors to be designed based on a natural biological recognition process. (Abstract copied from: http://www.nature.com/nnano/journal/v3/n9/abs/nnano.2008.189.html)

ORCID iDs

Graham, D. ORCID logoORCID: https://orcid.org/0000-0002-6079-2105, Thompson, D.G., Smith, W.E. and Faulds, K. ORCID logoORCID: https://orcid.org/0000-0002-5567-7399;
  • Item type:Article
    ID code:17040
    Dates:
    Date
    Event
    September 2008
    Published
    11 July 2008
    Published Online
    Notes:http://suprimo.lib.strath.ac.uk/primo_library/libweb/action/display.do?ct=display&doc=SUSFX1000000000239775&indx=1&frbg=&dum=true&vid=SUVU01&vl(54032236UI0)=lsr02&vl(96071691UI1)=all_items&srt=rank&indx=1&dstmp=1271692113117&tab=local&ct=search&scp.scps=scope%3A(SU)&vl(freeText0)=Nature%20nanotechnology&fn=search&mode=Basic&dscnt=0
    Subjects:Science > Chemistry
    Science > Chemistry > Physical and theoretical chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Strathprints Administrator
    Date deposited:19 Apr 2010 15:56
    Last modified:11 Nov 2024 09:22
    URI:https://strathprints.strath.ac.uk/id/eprint/17040
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