Molecular determinants in pulmonary hypertension : the role of PDE5

Pyne, N.J. and Murray, Fiona and Tate, R. and MacLean, Margaret R; Beavo, J and Francis, S and Houslay, MD, eds. (2006) Molecular determinants in pulmonary hypertension : the role of PDE5. In: Cyclic Nucleotide Phosphodiesterases in Health and Diseases. CRC/Taylor & Francis Group, Boca Raton, pp. 501-518. ISBN 9780849396687 (https://doi.org/10.1201/9781420020847.ch25)

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Abstract

This chapter discusses molecular determinants in pulmonary hypertension. Role of PDE5 Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each.

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