Synthesis of a benzotriazole phosphoramidite for attachment of oligonucleotides to metal surfaces

Brown, R. and Smith, W.E. and Graham, D. (2001) Synthesis of a benzotriazole phosphoramidite for attachment of oligonucleotides to metal surfaces. Tetrahedron Letters, 42 (11). pp. 2197-2200. ISSN 0040-4039 (http://dx.doi.org/10.1016/S0040-4039(01)00108-3)

Abstract

A method for the addition of a benzotriazole moiety to the 5'-terminus of an oligonucleotide via phosphoramidite chemistry has been developed. Use of a monomethoxytrityl protecting group on the benzotriazole allowed fast on-column detritylation purification by reverse-phase HPLC. Surface enhanced Raman scattering (SERS) of the modified oligonucleotides was obtained from silver colloid.

ORCID iDs

Graham, D. ORCID: https://orcid.org/0000-0002-6079-2105

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• Item metadata

  Item type:	Article
  ID code:	967
  Dates:	Date Event 11 March 2001 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Unknown Department
  Depositing user:	Mr Derek Boyle
  Date deposited:	05 May 2006
  Last modified:	11 Nov 2024 08:19
  Related URLs:	http://www.sciencedirect.com/science?_ob...
  URI:	https://strathprints.strath.ac.uk/id/eprint/967