Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles

McPherson, Christopher G. and Livingstone, Keith and Jamieson, Craig and Simpson, Iain (2016) Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles. Synlett, 27 (1). pp. 88-92. ISSN 0936-5214 (https://doi.org/10.1055/s-0035-1560724)

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Abstract

A procedure for the formation of aryl amides through the palladium-catalyzed coupling of nitriles and aryl bromides, via the formation of intermediary silanoate derived imidate species is reported. Optimization was undertaken and examples of the process are described that furnish the products in up to 86% isolated yield.

ORCID iDs

McPherson, Christopher G. ORCID logoORCID: https://orcid.org/0000-0002-3082-0515, Livingstone, Keith, Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272 and Simpson, Iain;
CORE (COnnecting REpositories)